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- W3090697673 endingPage "117183" @default.
- W3090697673 startingPage "117183" @default.
- W3090697673 abstract "• Dextran palmitates produce moderately hydrophobic films with low nano-roughness. • The films are suitable for patterning via thermal nanoimprint lithography (T-NIL). • T-NIL patterning introduces defined regions with increased apparent contact angles. • The model platform allows guidance of cell adhesion and multicellular arrangements. • T-NIL patterned polysaccharides are used as a biological substrate for the first time. The elucidation of cell-surface interactions and the development of model platforms to help uncover their underlying mechanisms remains vital to the design of effective biomaterials. To this end, dextran palmitates with varying degrees of substitution were synthesised with a multipurpose functionality: an ability to modulate surface energy through surface chemistry, and an ideal thermal behaviour for patterning. Herein, dextran palmitate films are produced by spin coating, and patterned by thermal nanoimprint lithography with nano-to-microscale topographies. These films of moderately hydrophobic polysaccharide esters with low nanoscale roughness performed as well as fibronectin coatings in the culture of bovine aortic endothelial cells. Upon patterning, they display distinct regions of roughness, restricting cell adhesion to the smoothest surfaces, while guiding multicellular arrangements in the patterned topographies. The development of biomaterial interfaces through topochemical fabrication such as this could prove useful in understanding protein and cell-surface interactions." @default.
- W3090697673 created "2020-10-08" @default.
- W3090697673 creator A5020752049 @default.
- W3090697673 creator A5044986608 @default.
- W3090697673 creator A5065952752 @default.
- W3090697673 creator A5066162330 @default.
- W3090697673 creator A5079387047 @default.
- W3090697673 date "2021-01-01" @default.
- W3090697673 modified "2023-09-26" @default.
- W3090697673 title "Patterned dextran ester films as a tailorable cell culture platform" @default.
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