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• W3090720142 abstract "PD-1/PD-L1-checkpoint blockade therapy is generally thought to relieve tumor cell-mediated suppression in the tumor microenvironment but PD-L1 is also expressed on non-tumor macrophages and conventional dendritic cells (cDCs). Here we show in mouse tumor models that tumor-draining lymph nodes (TDLNs) are enriched for tumor-specific PD-1+ T cells which closely associate with PD-L1+ cDCs. TDLN-targeted PD-L1-blockade induces enhanced anti-tumor T cell immunity by seeding the tumor site with progenitor-exhausted T cells, resulting in improved tumor control. Moreover, we show that abundant PD-1/PD-L1-interactions in TDLNs of nonmetastatic melanoma patients, but not those in corresponding tumors, associate with early distant disease recurrence. These findings point at a critical role for PD-L1 expression in TDLNs in governing systemic anti-tumor immunity, identifying high-risk patient groups amendable to adjuvant PD-1/PD-L1-blockade therapy." @default.
• W3090720142 created "2020-10-08" @default.
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• W3090720142 date "2020-11-01" @default.
• W3090720142 modified "2023-10-18" @default.
• W3090720142 title "The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes" @default.
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• W3090720142 doi "https://doi.org/10.1016/j.ccell.2020.09.001" @default.
• W3090720142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33007259" @default.
• W3090720142 hasPublicationYear "2020" @default.
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