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- W3090723665 abstract "Stereoselectively-fluorinated analogs of pipecolic acid have been investigated through a combined theoretical and experimental approach. Three of the four possible diastereoisomers of 4,5-difluoropipecolic acid were successfully synthesized via deoxyfluorination chemistry, navigating a complex reaction network that included neighboring group participation, rearrangement, and elimination pathways. A DFT-based conformational study, supported by NMR J-based analysis, revealed that the different diastereoisomers of 4,5-difluoropipecolic acid preferentially adopt different puckers of the six-membered ring. These findings could have future relevance for the conformational control of biologically active peptides." @default.
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- W3090723665 date "2020-01-01" @default.
- W3090723665 modified "2023-09-25" @default.
- W3090723665 title "Diastereoselective synthesis and conformational analysis of 4,5-difluoropipecolic acids" @default.
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- W3090723665 doi "https://doi.org/10.1039/d0ob01811b" @default.
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