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- W3090727502 abstract "Homeostasis occurs in a biological system when some output variable remains approximately constant as one or several input parameters change over some intervals. When the variable is exactly constant, one talks about absolute concentration robustness (ACR). A dual and equally important property is multistationarity, which means that the system has multiple steady states and possible outputs, at constant parameters. We propose a new computational method based on interval techniques to find species in biochemical systems that verify homeostasis, and a similar method for testing multistationarity. We test homeostasis, ACR and multistationarity on a large collection of biochemical models from the Biomodels and DOCSS databases. The codes used in this paper are publicly available at: https://github.com/Glawal/IbexHomeo." @default.
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- W3090727502 date "2020-01-01" @default.
- W3090727502 modified "2023-10-16" @default.
- W3090727502 title "Interval Constraint Satisfaction and Optimization for Biological Homeostasis and Multistationarity" @default.
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- W3090727502 doi "https://doi.org/10.1007/978-3-030-60327-4_5" @default.
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