FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090736110> ?p ?o ?g. }

• W3090736110 endingPage "18212" @default.
• W3090736110 startingPage "18200" @default.
• W3090736110 abstract "A widely applicable, practical, and scalable strategy for efficient and enantioselective synthesis of β,γ-unsaturated ketones that contain an α-stereogenic center is disclosed. Accordingly, aryl, heteroaryl, alkynyl, alkenyl, allyl, or alkyl ketones that contain an α-stereogenic carbon with an alkyl, an aryl, a benzyloxy, or a siloxy moiety can be generated from readily available starting materials and by the use of commercially available chiral ligands in 52-96% yield and 93:7 to >99:1 enantiomeric ratio. To develop the new method, conditions were identified so that high enantioselectivity would be attained and the resulting α-substituted NH-ketimines, wherein there is strong C═N → B(pin) coordination, would not epimerize before conversion to the derived ketone by hydrolysis. It is demonstrated that the ketone products can be converted to an assortment of homoallylic tertiary alcohols in 70-96% yield and 92:8 to >98:2 dr-in either diastereomeric form-by reactions with alkyl-, aryl-, heteroaryl-, allyl-, vinyl-, alkynyl-, or propargyl-metal reagents. The utility of the approach is highlighted through transformations that furnish other desirable derivatives and a concise synthesis route affording more than a gram of a major fragment of anti-HIV agents rubriflordilactones A and B and a specific stereoisomeric analogue." @default.
• W3090736110 created "2020-10-08" @default.
• W3090736110 creator A5002462979 @default.
• W3090736110 creator A5024911933 @default.
• W3090736110 creator A5029080922 @default.
• W3090736110 creator A5081485832 @default.
• W3090736110 creator A5089547993 @default.
• W3090736110 creator A5091398327 @default.
• W3090736110 date "2020-10-05" @default.
• W3090736110 modified "2023-09-30" @default.
• W3090736110 title "Streamlined Catalytic Enantioselective Synthesis of α-Substituted β,γ-Unsaturated Ketones and Either of the Corresponding Tertiary Homoallylic Alcohol Diastereomers" @default.
• W3090736110 cites W1731812930 @default.
• W3090736110 cites W1983271503 @default.
• W3090736110 cites W1986904218 @default.
• W3090736110 cites W1995075366 @default.
• W3090736110 cites W1996068510 @default.
• W3090736110 cites W2000228966 @default.
• W3090736110 cites W2009277272 @default.
• W3090736110 cites W2010580563 @default.
• W3090736110 cites W2038198744 @default.
• W3090736110 cites W2039563092 @default.
• W3090736110 cites W2043201384 @default.
• W3090736110 cites W2044082085 @default.
• W3090736110 cites W2051163029 @default.
• W3090736110 cites W2055884298 @default.
• W3090736110 cites W2070340514 @default.
• W3090736110 cites W2079494330 @default.
• W3090736110 cites W2086344683 @default.
• W3090736110 cites W2094622799 @default.
• W3090736110 cites W2101727553 @default.
• W3090736110 cites W2118174211 @default.
• W3090736110 cites W2119413610 @default.
• W3090736110 cites W2121551764 @default.
• W3090736110 cites W2126503330 @default.
• W3090736110 cites W2132720431 @default.
• W3090736110 cites W2141626852 @default.
• W3090736110 cites W2145443116 @default.
• W3090736110 cites W2145606109 @default.
• W3090736110 cites W2149983834 @default.
• W3090736110 cites W2171175011 @default.
• W3090736110 cites W2171357337 @default.
• W3090736110 cites W2263809562 @default.
• W3090736110 cites W2322009365 @default.
• W3090736110 cites W2324192335 @default.
• W3090736110 cites W2326436985 @default.
• W3090736110 cites W2343287953 @default.
• W3090736110 cites W2409674287 @default.
• W3090736110 cites W2415989643 @default.
• W3090736110 cites W2517648757 @default.
• W3090736110 cites W2573123932 @default.
• W3090736110 cites W2612673239 @default.
• W3090736110 cites W2620496829 @default.
• W3090736110 cites W2622699432 @default.
• W3090736110 cites W2626267889 @default.
• W3090736110 cites W2730588281 @default.
• W3090736110 cites W2736290476 @default.
• W3090736110 cites W2765155818 @default.
• W3090736110 cites W2766378450 @default.
• W3090736110 cites W2787210721 @default.
• W3090736110 cites W2801502119 @default.
• W3090736110 cites W2890318302 @default.
• W3090736110 cites W2891820494 @default.
• W3090736110 cites W2899896140 @default.
• W3090736110 cites W2913538815 @default.
• W3090736110 cites W2920791159 @default.
• W3090736110 cites W2931574106 @default.
• W3090736110 cites W2932007531 @default.
• W3090736110 cites W2944484516 @default.
• W3090736110 cites W2949563757 @default.
• W3090736110 cites W2949712482 @default.
• W3090736110 cites W2950971696 @default.
• W3090736110 cites W2955542922 @default.
• W3090736110 cites W2969606311 @default.
• W3090736110 cites W2979739149 @default.
• W3090736110 cites W3004348550 @default.
• W3090736110 cites W3007961319 @default.
• W3090736110 cites W3014608732 @default.
• W3090736110 cites W3030214941 @default.
• W3090736110 cites W3045051536 @default.
• W3090736110 cites W4229504515 @default.
• W3090736110 doi "https://doi.org/10.1021/jacs.0c08732" @default.
• W3090736110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7775104" @default.
• W3090736110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33016068" @default.
• W3090736110 hasPublicationYear "2020" @default.
• W3090736110 type Work @default.
• W3090736110 sameAs 3090736110 @default.
• W3090736110 citedByCount "26" @default.
• W3090736110 countsByYear W30907361102021 @default.
• W3090736110 countsByYear W30907361102022 @default.
• W3090736110 countsByYear W30907361102023 @default.
• W3090736110 crossrefType "journal-article" @default.
• W3090736110 hasAuthorship W3090736110A5002462979 @default.
• W3090736110 hasAuthorship W3090736110A5024911933 @default.
• W3090736110 hasAuthorship W3090736110A5029080922 @default.
• W3090736110 hasAuthorship W3090736110A5081485832 @default.
• W3090736110 hasAuthorship W3090736110A5089547993 @default.
• W3090736110 hasAuthorship W3090736110A5091398327 @default.
• W3090736110 hasBestOaLocation W30907361102 @default.

• next