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- W3090747512 abstract "Abstract The cell cortex is a contractile actin meshwork, which determines cell shape and is essential for cell mechanics, migration and division. Because the cortical thickness is below optical resolution, it has been generally considered as a thin uniform two-dimensional layer. Using two mutually attracted magnetic beads, one inside the cell and the other in the extracellular medium, we pinch the cortex of dendritic cells and provide an accurate and time resolved measure of its thickness. Our observations draw a new picture of the cell cortex as a highly dynamic layer, harboring large fluctuations in its third dimension due to actomyosin contractility. We propose that the cortex dynamics might be responsible for the fast shape changing capacity of highly contractile cells that use amoeboid-like migration." @default.
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- W3090747512 date "2020-09-29" @default.
- W3090747512 modified "2023-10-15" @default.
- W3090747512 title "Pinching the cortex of live cells reveals thickness instabilities caused by Myosin II motors" @default.
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- W3090747512 doi "https://doi.org/10.1101/2020.09.28.316729" @default.
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