Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090762464> ?p ?o ?g. }
- W3090762464 endingPage "110831" @default.
- W3090762464 startingPage "110831" @default.
- W3090762464 abstract "The gut microbiota is an important contributor to both health and disease. While previous studies have reported on the beneficial influences of the gut microbiota and probiotic supplementation on bone health, their role in recovery from skeletal injury and resultant systemic sequelae remains unexplored. This study aimed to determine the extent to which probiotics could modulate bone repair by dampening fracture-induced systemic inflammation. Our findings demonstrate that femur fracture induced an increase in gut permeability lasting up to 7 days after trauma before returning to basal levels. Strikingly, dietary supplementation with Bifidobacterium adolescentis augmented the tightening of the intestinal barrier, dampened the systemic inflammatory response to fracture, accelerated fracture callus cartilage remodeling, and elicited enhanced protection of the intact skeleton following fracture. Together, these data outline a mechanism whereby dietary supplementation with beneficial bacteria can be therapeutically targeted to prevent the systemic pathologies induced by femur fracture." @default.
- W3090762464 created "2020-10-08" @default.
- W3090762464 creator A5014844728 @default.
- W3090762464 creator A5034940707 @default.
- W3090762464 creator A5045519111 @default.
- W3090762464 creator A5048430317 @default.
- W3090762464 creator A5057779997 @default.
- W3090762464 creator A5060868266 @default.
- W3090762464 creator A5089789086 @default.
- W3090762464 date "2020-12-01" @default.
- W3090762464 modified "2023-10-18" @default.
- W3090762464 title "Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae" @default.
- W3090762464 cites W1682365470 @default.
- W3090762464 cites W1948006184 @default.
- W3090762464 cites W1966776937 @default.
- W3090762464 cites W1969592147 @default.
- W3090762464 cites W1979427972 @default.
- W3090762464 cites W1980203682 @default.
- W3090762464 cites W1987650422 @default.
- W3090762464 cites W1994686608 @default.
- W3090762464 cites W1996361385 @default.
- W3090762464 cites W2001839690 @default.
- W3090762464 cites W2004148998 @default.
- W3090762464 cites W2011337131 @default.
- W3090762464 cites W2013657751 @default.
- W3090762464 cites W2020460418 @default.
- W3090762464 cites W2020861903 @default.
- W3090762464 cites W2026700628 @default.
- W3090762464 cites W2026830654 @default.
- W3090762464 cites W2028842505 @default.
- W3090762464 cites W2029755907 @default.
- W3090762464 cites W2036557984 @default.
- W3090762464 cites W2048550695 @default.
- W3090762464 cites W2050376374 @default.
- W3090762464 cites W2053791511 @default.
- W3090762464 cites W2062976959 @default.
- W3090762464 cites W2063820438 @default.
- W3090762464 cites W2064837899 @default.
- W3090762464 cites W2066749771 @default.
- W3090762464 cites W2067005353 @default.
- W3090762464 cites W2076020535 @default.
- W3090762464 cites W2085802620 @default.
- W3090762464 cites W2099166159 @default.
- W3090762464 cites W2101826298 @default.
- W3090762464 cites W2108718991 @default.
- W3090762464 cites W2112043714 @default.
- W3090762464 cites W2112738213 @default.
- W3090762464 cites W2114073773 @default.
- W3090762464 cites W2116901311 @default.
- W3090762464 cites W2118085302 @default.
- W3090762464 cites W2125496800 @default.
- W3090762464 cites W2126506597 @default.
- W3090762464 cites W2126800859 @default.
- W3090762464 cites W2141300346 @default.
- W3090762464 cites W2154824826 @default.
- W3090762464 cites W2156573030 @default.
- W3090762464 cites W2158032510 @default.
- W3090762464 cites W2160674655 @default.
- W3090762464 cites W2166710590 @default.
- W3090762464 cites W2168595823 @default.
- W3090762464 cites W2170658085 @default.
- W3090762464 cites W2321917741 @default.
- W3090762464 cites W2344954614 @default.
- W3090762464 cites W2511217924 @default.
- W3090762464 cites W2519455090 @default.
- W3090762464 cites W2552260644 @default.
- W3090762464 cites W2554125582 @default.
- W3090762464 cites W2615435255 @default.
- W3090762464 cites W2621241757 @default.
- W3090762464 cites W2740855840 @default.
- W3090762464 cites W2741230488 @default.
- W3090762464 cites W2747785677 @default.
- W3090762464 cites W2749088986 @default.
- W3090762464 cites W2765384361 @default.
- W3090762464 cites W2768326598 @default.
- W3090762464 cites W2789721316 @default.
- W3090762464 cites W2793888838 @default.
- W3090762464 cites W2811267341 @default.
- W3090762464 cites W2831325129 @default.
- W3090762464 cites W2890623123 @default.
- W3090762464 cites W2895678426 @default.
- W3090762464 cites W2901898635 @default.
- W3090762464 cites W2913812996 @default.
- W3090762464 cites W2914734699 @default.
- W3090762464 cites W2945333360 @default.
- W3090762464 cites W2945962757 @default.
- W3090762464 cites W2951834600 @default.
- W3090762464 cites W2963419343 @default.
- W3090762464 cites W2968411319 @default.
- W3090762464 cites W2987173983 @default.
- W3090762464 cites W2990018639 @default.
- W3090762464 cites W2998501790 @default.
- W3090762464 cites W3007217849 @default.
- W3090762464 cites W650697093 @default.
- W3090762464 doi "https://doi.org/10.1016/j.biopha.2020.110831" @default.
- W3090762464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33022534" @default.
- W3090762464 hasPublicationYear "2020" @default.
- W3090762464 type Work @default.