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• W3090767898 endingPage "398" @default.
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• W3090767898 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been caused the greatest pandemic of our century. Many of the deaths related to it are due to a systemic inflammatory response, which has been called 'cytokine storm'.We developed a comprehensive review of the pathophysiology mechanisms of COVID-19 and of the rationale for drugs and therapeutics that have been tested in clinical trials.A narrative review of the literature was conducted using PubMed, SciELO, Bireme, Google Scholar and ClinicalTrials.SARS-CoV-2 has evolutive mechanisms that made it spread all around the globe, as a higher latency period and a lesser lethality than other coronaviruses. SARS-CoV-2 causes a delay in the innate immune response and it disarranges the immune system leading to an overwhelming inflammatory reaction (the 'cytokine storm'). In this scenario, high levels of interleukins (IL), notably IL-6 and IL-1, create a positive feedback of chemokines and immune responses, and powers pulmonary and systemic tissue damage, leading to capillary leakage and SARS, the main cause of death in patients with COVID-19. On 17 July 2020, there were 1450 entries on ClinicalTrials.gov of ongoing studies on COVID-19. The mechanisms of the main therapeutic approaches were comprehensively reviewed throughout the text. Therapies focus on blocking viral entry (remdesivir, umifenovir, among others) and blocking of immune system for cytokine storm control (IL-1 and IL-6 inhibitors, glucocorticoids, convalescent plasma, among others).Understanding of action mechanisms of SARS-CoV-2 enables us to direct efforts on effective therapeutic targets. This comprehensive review helps to interpret the clinical results of the several trials ongoing." @default.
• W3090767898 created "2020-10-08" @default.
• W3090767898 creator A5002859353 @default.
• W3090767898 creator A5016115873 @default.
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• W3090767898 creator A5085348456 @default.
• W3090767898 date "2020-10-02" @default.
• W3090767898 modified "2023-10-01" @default.
• W3090767898 title "Review on therapeutic targets for COVID-19: insights from cytokine storm" @default.
• W3090767898 cites W2099769485 @default.
• W3090767898 cites W2129239355 @default.
• W3090767898 cites W2148822770 @default.
• W3090767898 cites W2166650533 @default.
• W3090767898 cites W2610356532 @default.
• W3090767898 cites W2808166290 @default.
• W3090767898 cites W3008028633 @default.
• W3090767898 cites W3009300613 @default.
• W3090767898 cites W3009859788 @default.
• W3090767898 cites W3009881183 @default.
• W3090767898 cites W3009885589 @default.
• W3090767898 cites W3011386994 @default.
• W3090767898 cites W3011610993 @default.
• W3090767898 cites W3012455685 @default.
• W3090767898 cites W3013306614 @default.
• W3090767898 cites W3013742505 @default.
• W3090767898 cites W3014130682 @default.
• W3090767898 cites W3014333693 @default.
• W3090767898 cites W3014356995 @default.
• W3090767898 cites W3014646061 @default.
• W3090767898 cites W3014735311 @default.
• W3090767898 cites W3014962324 @default.
• W3090767898 cites W3014967682 @default.
• W3090767898 cites W3014972620 @default.
• W3090767898 cites W3015252146 @default.
• W3090767898 cites W3015369767 @default.
• W3090767898 cites W3015613878 @default.
• W3090767898 cites W3015826819 @default.
• W3090767898 cites W3015993909 @default.
• W3090767898 cites W3016127406 @default.
• W3090767898 cites W3016395404 @default.
• W3090767898 cites W3016661132 @default.
• W3090767898 cites W3016746341 @default.
• W3090767898 cites W3016779347 @default.
• W3090767898 cites W3017010545 @default.
• W3090767898 cites W3017027582 @default.
• W3090767898 cites W3017138221 @default.
• W3090767898 cites W3017440151 @default.
• W3090767898 cites W3017734961 @default.
• W3090767898 cites W3018023298 @default.
• W3090767898 cites W3018040824 @default.
• W3090767898 cites W3018494531 @default.
• W3090767898 cites W3019081439 @default.
• W3090767898 cites W3019471008 @default.
• W3090767898 cites W3021391038 @default.
• W3090767898 cites W3021577619 @default.
• W3090767898 cites W3021630434 @default.
• W3090767898 cites W3021640348 @default.
• W3090767898 cites W3021826725 @default.
• W3090767898 cites W3022513688 @default.
• W3090767898 cites W3022534749 @default.
• W3090767898 cites W3022970339 @default.
• W3090767898 cites W3022972444 @default.
• W3090767898 cites W3023088605 @default.
• W3090767898 cites W3023346879 @default.
• W3090767898 cites W3023609353 @default.
• W3090767898 cites W3023911418 @default.
• W3090767898 cites W3024541652 @default.
• W3090767898 cites W3024698409 @default.
• W3090767898 cites W3025170810 @default.
• W3090767898 cites W3025830962 @default.
• W3090767898 cites W3027630905 @default.
• W3090767898 cites W3029616546 @default.
• W3090767898 cites W3030325615 @default.
• W3090767898 cites W3030371932 @default.
• W3090767898 cites W3031195035 @default.
• W3090767898 cites W3032274391 @default.
• W3090767898 cites W3032373213 @default.
• W3090767898 cites W3033175577 @default.
• W3090767898 cites W3033306974 @default.
• W3090767898 cites W3033884900 @default.
• W3090767898 cites W3033950875 @default.
• W3090767898 cites W3035417125 @default.
• W3090767898 cites W3035622686 @default.
• W3090767898 cites W3036174218 @default.
• W3090767898 cites W3036453504 @default.
• W3090767898 cites W3036779511 @default.
• W3090767898 cites W3036809604 @default.
• W3090767898 cites W3039983944 @default.
• W3090767898 cites W3040250890 @default.
• W3090767898 cites W3040820017 @default.
• W3090767898 cites W3040954605 @default.
• W3090767898 cites W3041022255 @default.
• W3090767898 cites W3042080119 @default.
• W3090767898 cites W3042126419 @default.
• W3090767898 doi "https://doi.org/10.1136/postgradmedj-2020-138791" @default.
• W3090767898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33008960" @default.
• W3090767898 hasPublicationYear "2020" @default.

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