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- W3090774295 abstract "Autophagy within the CNS has been studied mainly in neuronal cells in which absence of autophagy proteins results in spontaneous development of neurodegenerative phenotypes and susceptibility to neurotropic infections. There is emerging evidence for essential functions of autophagy pathways in CNS myeloid cells in brain health and disease. In contrast to conventional autophagy, CNS pathologies have so far been associated predominantly with noncanonical autophagy pathways used by myeloid cells, such as LC3-associated phagocytosis and LC3-associated endocytosis. These pathways require some but not all components of the autophagy machinery and bridge receptor-mediated phagocytosis/endocytosis with autophagy. Whether autophagy protein deficiency in microglia, CNS-associated macrophages, or dendritic cells in vivo mitigates or exacerbates brain injury depends on the targeted cell population and biological context. The CNS accommodates a diverse myeloid immune cell compartment that maintains CNS homeostasis in the steady state while contributing to tissue injury during infectious, autoimmune, and neurodegenerative disease conditions. Autophagy and autophagy proteins play fundamental roles in myeloid cell–related immune functions. Many of these processes do not necessarily involve the canonical formation of a double-membrane structure known as the ‘autophagosome’ and reflect noncanonical functions of the autophagy machinery. Here, we illustrate recent insights, concepts, and outstanding questions regarding how autophagy pathways in myeloid cells contribute to brain health and disease. The CNS accommodates a diverse myeloid immune cell compartment that maintains CNS homeostasis in the steady state while contributing to tissue injury during infectious, autoimmune, and neurodegenerative disease conditions. Autophagy and autophagy proteins play fundamental roles in myeloid cell–related immune functions. Many of these processes do not necessarily involve the canonical formation of a double-membrane structure known as the ‘autophagosome’ and reflect noncanonical functions of the autophagy machinery. Here, we illustrate recent insights, concepts, and outstanding questions regarding how autophagy pathways in myeloid cells contribute to brain health and disease." @default.
- W3090774295 created "2020-10-08" @default.
- W3090774295 creator A5014327058 @default.
- W3090774295 creator A5015324959 @default.
- W3090774295 creator A5084915056 @default.
- W3090774295 date "2020-12-01" @default.
- W3090774295 modified "2023-10-17" @default.
- W3090774295 title "Autophagy Pathways in CNS Myeloid Cell Immune Functions" @default.
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- W3090774295 doi "https://doi.org/10.1016/j.tins.2020.09.003" @default.