Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090795303> ?p ?o ?g. }
- W3090795303 endingPage "10183" @default.
- W3090795303 startingPage "10164" @default.
- W3090795303 abstract "Abstract T cells are central to the immune response against various pathogens and cancer cells. Complex networks of transcriptional and post-transcriptional regulators, including microRNAs (miRNAs), coordinate the T cell activation process. Available miRNA datasets, however, do not sufficiently dissolve the dynamic changes of miRNA controlled networks upon T cell activation. Here, we established a quantitative and time-resolved expression pattern for the entire miRNome over a period of 24 h upon human T-cell activation. Based on our time-resolved datasets, we identified central miRNAs and specified common miRNA expression profiles. We found the most prominent quantitative expression changes for miR-155-5p with a range from initially 40 molecules/cell to 1600 molecules/cell upon T-cell activation. We established a comprehensive dynamic regulatory network of both the up- and downstream regulation of miR-155. Upstream, we highlight IRF4 and its complexes with SPI1 and BATF as central for the transcriptional regulation of miR-155. Downstream of miR-155-5p, we verified 17 of its target genes by the time-resolved data recorded after T cell activation. Our data provide comprehensive insights into the range of stimulus induced miRNA abundance changes and lay the ground to identify efficient points of intervention for modifying the T cell response." @default.
- W3090795303 created "2020-10-08" @default.
- W3090795303 creator A5000709210 @default.
- W3090795303 creator A5008099499 @default.
- W3090795303 creator A5009201025 @default.
- W3090795303 creator A5016378595 @default.
- W3090795303 creator A5020280119 @default.
- W3090795303 creator A5020512308 @default.
- W3090795303 creator A5032098464 @default.
- W3090795303 creator A5032737258 @default.
- W3090795303 creator A5034352333 @default.
- W3090795303 creator A5054514348 @default.
- W3090795303 creator A5060657525 @default.
- W3090795303 creator A5067874269 @default.
- W3090795303 creator A5074653262 @default.
- W3090795303 creator A5085594740 @default.
- W3090795303 creator A5087001698 @default.
- W3090795303 date "2020-09-29" @default.
- W3090795303 modified "2023-10-15" @default.
- W3090795303 title "Quantitative and time-resolved miRNA pattern of early human T cell activation" @default.
- W3090795303 cites W144423133 @default.
- W3090795303 cites W1596515083 @default.
- W3090795303 cites W1647115901 @default.
- W3090795303 cites W1952278424 @default.
- W3090795303 cites W1964727443 @default.
- W3090795303 cites W1966054625 @default.
- W3090795303 cites W1969189285 @default.
- W3090795303 cites W1976708316 @default.
- W3090795303 cites W1984484036 @default.
- W3090795303 cites W1984771273 @default.
- W3090795303 cites W1990612961 @default.
- W3090795303 cites W1992360391 @default.
- W3090795303 cites W1993351885 @default.
- W3090795303 cites W1997921822 @default.
- W3090795303 cites W1998140525 @default.
- W3090795303 cites W2003633088 @default.
- W3090795303 cites W2004762438 @default.
- W3090795303 cites W2009749672 @default.
- W3090795303 cites W2011626068 @default.
- W3090795303 cites W2014869583 @default.
- W3090795303 cites W2016381774 @default.
- W3090795303 cites W2018838463 @default.
- W3090795303 cites W2021987504 @default.
- W3090795303 cites W2025856640 @default.
- W3090795303 cites W2026570544 @default.
- W3090795303 cites W2027710246 @default.
- W3090795303 cites W2031918149 @default.
- W3090795303 cites W2036656644 @default.
- W3090795303 cites W2037739086 @default.
- W3090795303 cites W2045067923 @default.
- W3090795303 cites W2046959528 @default.
- W3090795303 cites W2050066317 @default.
- W3090795303 cites W2055747219 @default.
- W3090795303 cites W2058955985 @default.
- W3090795303 cites W2059697721 @default.
- W3090795303 cites W2059920458 @default.
- W3090795303 cites W2060913542 @default.
- W3090795303 cites W2068013806 @default.
- W3090795303 cites W2074356915 @default.
- W3090795303 cites W2079145939 @default.
- W3090795303 cites W2079228474 @default.
- W3090795303 cites W2085578966 @default.
- W3090795303 cites W2090975474 @default.
- W3090795303 cites W2092547796 @default.
- W3090795303 cites W2095969880 @default.
- W3090795303 cites W2109375321 @default.
- W3090795303 cites W2109837993 @default.
- W3090795303 cites W2110065044 @default.
- W3090795303 cites W2116322544 @default.
- W3090795303 cites W2118139916 @default.
- W3090795303 cites W2118694755 @default.
- W3090795303 cites W2118842534 @default.
- W3090795303 cites W2119876318 @default.
- W3090795303 cites W2128096483 @default.
- W3090795303 cites W2136312332 @default.
- W3090795303 cites W2137734450 @default.
- W3090795303 cites W2139242895 @default.
- W3090795303 cites W2140056203 @default.
- W3090795303 cites W2146512944 @default.
- W3090795303 cites W2147197297 @default.
- W3090795303 cites W2147932553 @default.
- W3090795303 cites W2153834669 @default.
- W3090795303 cites W2156629568 @default.
- W3090795303 cites W2162599367 @default.
- W3090795303 cites W2164832071 @default.
- W3090795303 cites W2167976457 @default.
- W3090795303 cites W2168458927 @default.
- W3090795303 cites W2171519536 @default.
- W3090795303 cites W2172523660 @default.
- W3090795303 cites W2214960086 @default.
- W3090795303 cites W2230621123 @default.
- W3090795303 cites W2273997940 @default.
- W3090795303 cites W2297219066 @default.
- W3090795303 cites W2341868400 @default.
- W3090795303 cites W2343186061 @default.
- W3090795303 cites W2346566986 @default.
- W3090795303 cites W2531244026 @default.
- W3090795303 cites W2549135004 @default.