Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090799961> ?p ?o ?g. }
- W3090799961 endingPage "1768" @default.
- W3090799961 startingPage "1757" @default.
- W3090799961 abstract "Abstract Objective We conducted a systematic review and meta-analysis to assess the available literature regarding the surgical and oncologic outcomes of patients undergoing salvage radical cystectomy (SV-RC) for recurrence or failure of bladder sparing therapy (BST) for muscle-invasive bladder cancer (MIBC). Methods We searched MEDLINE (PubMed), EMBASE and Google Scholar databases in May 2020. We included all studies of patients with ≥ cT2N0/xM0 bladder cancer that were eligible for all treatment modalities at the time of treatment decision who underwent BST including radiotherapy (RTX). A meta-analysis was conducted to calculate the pooled rate of several variables associated with an increased need for SV-RC. Study quality and risk of bias were assessed using MINORS criteria. Results 73 studies comprising 9110 patients were eligible for the meta-analysis. Weighted mean follow-up time was 61.1 months (range 12–144). The pooled rate of non-response to BST and local recurrence after BST, the two primary reasons for SV-RC, was 15.5% and 28.7%, respectively. The pooled rate of SV-RC was 19.2% for studies with a follow-up longer than 5 years. Only three studies provided a thorough report of complication rates after SV-RC. The overall complication rate ranged between 67 and 72% with a 30-day mortality rate of 0–8.8%. The pooled rates of 5 and 10-year disease-free survival after SV-RC were 54.3% and 45.6%, respectively. Conclusion Approximately one-fifth of patients treated with BST with a curative intent eventually require SV-RC. This procedure carries a proportionally high rate of complications and is usually accompanied by an incontinent urinary diversion." @default.
- W3090799961 created "2020-10-08" @default.
- W3090799961 creator A5011013432 @default.
- W3090799961 creator A5024662180 @default.
- W3090799961 creator A5030019301 @default.
- W3090799961 creator A5038102022 @default.
- W3090799961 creator A5038866794 @default.
- W3090799961 creator A5048506098 @default.
- W3090799961 creator A5058063575 @default.
- W3090799961 creator A5065748857 @default.
- W3090799961 creator A5071129858 @default.
- W3090799961 creator A5074919720 @default.
- W3090799961 creator A5076590254 @default.
- W3090799961 creator A5079401169 @default.
- W3090799961 creator A5087973088 @default.
- W3090799961 date "2020-09-29" @default.
- W3090799961 modified "2023-10-18" @default.
- W3090799961 title "Incidence and outcome of salvage cystectomy after bladder sparing therapy for muscle invasive bladder cancer: a systematic review and meta-analysis" @default.
- W3090799961 cites W1560239325 @default.
- W3090799961 cites W1577918478 @default.
- W3090799961 cites W1819069357 @default.
- W3090799961 cites W1963616719 @default.
- W3090799961 cites W1965740335 @default.
- W3090799961 cites W1972294467 @default.
- W3090799961 cites W1975848770 @default.
- W3090799961 cites W1978127872 @default.
- W3090799961 cites W1979423827 @default.
- W3090799961 cites W1984082819 @default.
- W3090799961 cites W1985950314 @default.
- W3090799961 cites W1986438764 @default.
- W3090799961 cites W1986835678 @default.
- W3090799961 cites W1988675200 @default.
- W3090799961 cites W1992548667 @default.
- W3090799961 cites W1992647763 @default.
- W3090799961 cites W2000134309 @default.
- W3090799961 cites W2002204518 @default.
- W3090799961 cites W2003543920 @default.
- W3090799961 cites W2004369071 @default.
- W3090799961 cites W2009852363 @default.
- W3090799961 cites W2010911679 @default.
- W3090799961 cites W2017044005 @default.
- W3090799961 cites W2021540448 @default.
- W3090799961 cites W2025106656 @default.
- W3090799961 cites W2028936192 @default.
- W3090799961 cites W2029225162 @default.
- W3090799961 cites W2029301141 @default.
- W3090799961 cites W2033390807 @default.
- W3090799961 cites W2039475642 @default.
- W3090799961 cites W2044425811 @default.
- W3090799961 cites W2044662309 @default.
- W3090799961 cites W2047193631 @default.
- W3090799961 cites W2049473720 @default.
- W3090799961 cites W2054282253 @default.
- W3090799961 cites W2055673939 @default.
- W3090799961 cites W2064397358 @default.
- W3090799961 cites W2068304535 @default.
- W3090799961 cites W2071527621 @default.
- W3090799961 cites W2075584199 @default.
- W3090799961 cites W2075807787 @default.
- W3090799961 cites W2083819535 @default.
- W3090799961 cites W2085821136 @default.
- W3090799961 cites W2086616036 @default.
- W3090799961 cites W2088004486 @default.
- W3090799961 cites W2092600619 @default.
- W3090799961 cites W2094675220 @default.
- W3090799961 cites W2095443652 @default.
- W3090799961 cites W2103492268 @default.
- W3090799961 cites W2110018948 @default.
- W3090799961 cites W2111831003 @default.
- W3090799961 cites W2113156769 @default.
- W3090799961 cites W2118328604 @default.
- W3090799961 cites W2119738283 @default.
- W3090799961 cites W2121637004 @default.
- W3090799961 cites W2125675894 @default.
- W3090799961 cites W2128089432 @default.
- W3090799961 cites W2130834017 @default.
- W3090799961 cites W2132777059 @default.
- W3090799961 cites W2136145129 @default.
- W3090799961 cites W2140283950 @default.
- W3090799961 cites W2140310677 @default.
- W3090799961 cites W2140970165 @default.
- W3090799961 cites W2143449919 @default.
- W3090799961 cites W2145623483 @default.
- W3090799961 cites W2147476574 @default.
- W3090799961 cites W2153727337 @default.
- W3090799961 cites W2157020021 @default.
- W3090799961 cites W2160797158 @default.
- W3090799961 cites W2161751169 @default.
- W3090799961 cites W2165465466 @default.
- W3090799961 cites W2165709466 @default.
- W3090799961 cites W2168847820 @default.
- W3090799961 cites W2169789378 @default.
- W3090799961 cites W2171486331 @default.
- W3090799961 cites W2234705423 @default.
- W3090799961 cites W2308167615 @default.
- W3090799961 cites W2397683055 @default.
- W3090799961 cites W2406945847 @default.
- W3090799961 cites W2411344783 @default.