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• W3090803090 endingPage "837" @default.
• W3090803090 startingPage "822" @default.
• W3090803090 abstract "Recent efforts to assemble and analyze the Ambystoma mexicanum genome have dramatically improved the potential to develop molecular tools and pursue genome-wide analyses of genetic variation.To better resolve the distribution and origins of genetic variation with A mexicanum, we compared DNA sequence data for two laboratory A mexicanum and one A tigrinum to identify 702 million high confidence polymorphisms distributed across the 32 Gb genome. While the wild-caught A tigrinum was generally more polymorphic in a genome-wide sense, several multi-megabase regions were identified from A mexicanum genomes that were actually more polymorphic than A tigrinum. Analysis of polymorphism and repeat content reveals that these regions likely originated from the intentional hybridization of A mexicanum and A tigrinum that was used to introduce the albino mutation into laboratory stocks.Our findings show that axolotl genomes are variable with respect to introgressed DNA from a highly polymorphic species. It seems likely that other divergent regions will be discovered with additional sequencing of A mexicanum. This has practical implications for designing molecular probes and suggests a need to study A mexicanum phenotypic variation and genome evolution across the tiger salamander clade." @default.
• W3090803090 created "2020-10-08" @default.
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• W3090803090 date "2020-10-14" @default.
• W3090803090 modified "2023-09-27" @default.
• W3090803090 title "Large‐scale variation in single nucleotide polymorphism density within the laboratory axolotl ( <i>Ambystoma mexicanum</i> )" @default.
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• W3090803090 doi "https://doi.org/10.1002/dvdy.257" @default.
• W3090803090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33001517" @default.
• W3090803090 hasPublicationYear "2020" @default.
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