Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090807735> ?p ?o ?g. }
- W3090807735 endingPage "123842" @default.
- W3090807735 startingPage "123842" @default.
- W3090807735 abstract "Fabrication of appropriate electro-conductive scaffold, application of small molecules (SMs), electrical stimulation (ES), and stem cells are steps forward in cardiac tissue engineering. Herein, for the first time, all mentioned factors have been taken into account concurrently regarding the differentiation of unrestricted somatic stem cells (USSCs) into cardiac cells. To accomplish this goal, electrospun composite scaffolds made of chitosan (CS) and polyvinyl alcohol (PVA) with multi-wall carbon nanotubes (MWCNTs; ranged from 0 to 2.5% w/w) were fabricated. After analyzing mechanical, electrical, and biological properties, the best MWCNTs portion was selected. Of note, the addition of 2%w/w MWCNTs to the CS/PVA samples reduced average fiber diameter from 225 to 110 nm, increasing electrical conductivity from 8 × 10−5 S/m to 9 × 10−3 S/m and trebling tensile strength. Then, by using a 10-day differentiation protocol (including CHIR99021, IWP2, SB431542, and purmorphamine SMs) and ES, USSCs were induced into cardiomyocytes. Overexpression of some cardiac-associated genes, including troponin I, CX43, and β-MHC, along with proper phenotypic alteration, were observed. (Scaffold + SM + ES) show a significant increase in the expression of these genes, 172, 5.3, and 64-times as normalized to undifferentiated cells, respectively. Our findings confirmed the importance of the simultaneous implementation of different factors for the developing functionality of the cardiac tissue. Altogether, it is recommended to deploy all mentioned features to obtain effective cardiac tissue engineering." @default.
- W3090807735 created "2020-10-08" @default.
- W3090807735 creator A5002698470 @default.
- W3090807735 creator A5008133283 @default.
- W3090807735 creator A5016037678 @default.
- W3090807735 creator A5033063089 @default.
- W3090807735 creator A5043748451 @default.
- W3090807735 creator A5058806352 @default.
- W3090807735 creator A5075452734 @default.
- W3090807735 creator A5085662088 @default.
- W3090807735 creator A5090246936 @default.
- W3090807735 date "2021-01-01" @default.
- W3090807735 modified "2023-10-04" @default.
- W3090807735 title "Concurrent application of conductive biopolymeric chitosan/ polyvinyl alcohol/ MWCNTs nanofibers, intracellular signaling manipulating molecules and electrical stimulation for more effective cardiac tissue engineering" @default.
- W3090807735 cites W1012521920 @default.
- W3090807735 cites W1845695367 @default.
- W3090807735 cites W1865944349 @default.
- W3090807735 cites W1922087820 @default.
- W3090807735 cites W1958396013 @default.
- W3090807735 cites W1966751409 @default.
- W3090807735 cites W1968499052 @default.
- W3090807735 cites W1972989180 @default.
- W3090807735 cites W1973405268 @default.
- W3090807735 cites W1984277999 @default.
- W3090807735 cites W1984971046 @default.
- W3090807735 cites W1985597509 @default.
- W3090807735 cites W1988998921 @default.
- W3090807735 cites W1991253911 @default.
- W3090807735 cites W1992403567 @default.
- W3090807735 cites W1999203014 @default.
- W3090807735 cites W2005913184 @default.
- W3090807735 cites W2011341106 @default.
- W3090807735 cites W2016804262 @default.
- W3090807735 cites W2018071690 @default.
- W3090807735 cites W2036238651 @default.
- W3090807735 cites W2038253268 @default.
- W3090807735 cites W2043401892 @default.
- W3090807735 cites W2047925917 @default.
- W3090807735 cites W2048845365 @default.
- W3090807735 cites W2057117105 @default.
- W3090807735 cites W2060133565 @default.
- W3090807735 cites W2060755905 @default.
- W3090807735 cites W2075501566 @default.
- W3090807735 cites W2077890798 @default.
- W3090807735 cites W2079592630 @default.
- W3090807735 cites W2083860653 @default.
- W3090807735 cites W2092000308 @default.
- W3090807735 cites W2099209249 @default.
- W3090807735 cites W2101929433 @default.
- W3090807735 cites W2112446084 @default.
- W3090807735 cites W2115746002 @default.
- W3090807735 cites W2143215401 @default.
- W3090807735 cites W2143391484 @default.
- W3090807735 cites W2159205301 @default.
- W3090807735 cites W2172160378 @default.
- W3090807735 cites W2172670320 @default.
- W3090807735 cites W2179618689 @default.
- W3090807735 cites W2196490965 @default.
- W3090807735 cites W2460218742 @default.
- W3090807735 cites W2471546656 @default.
- W3090807735 cites W2495307975 @default.
- W3090807735 cites W2602055249 @default.
- W3090807735 cites W2612678024 @default.
- W3090807735 cites W2616219472 @default.
- W3090807735 cites W2765988593 @default.
- W3090807735 cites W2779611838 @default.
- W3090807735 cites W2790077045 @default.
- W3090807735 cites W2790385015 @default.
- W3090807735 cites W2803445723 @default.
- W3090807735 cites W2804028876 @default.
- W3090807735 cites W2810513362 @default.
- W3090807735 cites W2889298343 @default.
- W3090807735 cites W2896256448 @default.
- W3090807735 cites W2902717940 @default.
- W3090807735 cites W2912283816 @default.
- W3090807735 cites W2924437592 @default.
- W3090807735 cites W2956391120 @default.
- W3090807735 cites W2966225980 @default.
- W3090807735 cites W2971515944 @default.
- W3090807735 cites W2977366644 @default.
- W3090807735 cites W2990978095 @default.
- W3090807735 cites W3003056236 @default.
- W3090807735 cites W3003774210 @default.
- W3090807735 doi "https://doi.org/10.1016/j.matchemphys.2020.123842" @default.
- W3090807735 hasPublicationYear "2021" @default.
- W3090807735 type Work @default.
- W3090807735 sameAs 3090807735 @default.
- W3090807735 citedByCount "36" @default.
- W3090807735 countsByYear W30908077352021 @default.
- W3090807735 countsByYear W30908077352022 @default.
- W3090807735 countsByYear W30908077352023 @default.
- W3090807735 crossrefType "journal-article" @default.
- W3090807735 hasAuthorship W3090807735A5002698470 @default.
- W3090807735 hasAuthorship W3090807735A5008133283 @default.
- W3090807735 hasAuthorship W3090807735A5016037678 @default.
- W3090807735 hasAuthorship W3090807735A5033063089 @default.
- W3090807735 hasAuthorship W3090807735A5043748451 @default.
- W3090807735 hasAuthorship W3090807735A5058806352 @default.