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- W3090824897 endingPage "118882" @default.
- W3090824897 startingPage "118882" @default.
- W3090824897 abstract "C. elegans is a powerful model for studies of zinc biology. Here we review recent discoveries and emphasize the advantages of this model organism. Methods for manipulating and measuring zinc levels have been developed in or adapted to the worm. The C. elegans genome encodes highly conserved zinc transporters, and their expression and function are beginning to be characterized. Homeostatic mechanisms have evolved to respond to high and low zinc conditions. The pathway for high zinc homeostasis has been recently elucidated based on the discovery of the master regulator of high zinc homeostasis, HIZR-1. A parallel pathway for low zinc homeostasis is beginning to emerge based on the discovery of the Low Zinc Activation promoter element. Zinc has been established to play a role in two cell fate determination events, and accumulating evidence suggests zinc may function as a second messenger signaling molecule during vulval cell development and sperm activation." @default.
- W3090824897 created "2020-10-08" @default.
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- W3090824897 date "2021-01-01" @default.
- W3090824897 modified "2023-10-10" @default.
- W3090824897 title "Zinc homeostasis and signaling in the roundworm C. elegans" @default.
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- W3090824897 doi "https://doi.org/10.1016/j.bbamcr.2020.118882" @default.
- W3090824897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8237512" @default.
- W3090824897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33017595" @default.
- W3090824897 hasPublicationYear "2021" @default.
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