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• W3090862393 abstract "To investigate the effects of abituzumab in systemic sclerosis-associated interstitial lung disease (SSc-ILD).STRATUS was a phase II, double-blind, parallel-group, multicenter trial (ClinicalTrials.gov: NCT02745145). Adults (≤ 75 yrs) with SSc-ILD on stable mycophenolate were randomized (2:2:1) to receive intravenous abituzumab 1500 mg, abituzumab 500 mg, or placebo every 4 weeks for 104 weeks. The primary endpoint was the annual rate of change in absolute forced vital capacity.STRATUS was terminated prematurely due to slow enrollment (n = 75 screened, n = 24 randomized), precluding robust analysis of efficacy. Abituzumab was well tolerated; no new safety signals were detected.Further investigation of abituzumab for treatment of SSc-ILD is required." @default.
• W3090862393 created "2020-10-08" @default.
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• W3090862393 date "2020-10-01" @default.
• W3090862393 modified "2023-10-18" @default.
• W3090862393 title "STRATUS: A Phase II Study of Abituzumab in Patients With Systemic Sclerosis–associated Interstitial Lung Disease" @default.
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• W3090862393 doi "https://doi.org/10.3899/jrheum.191365" @default.
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