Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090868074> ?p ?o ?g. }
- W3090868074 endingPage "2654" @default.
- W3090868074 startingPage "2642" @default.
- W3090868074 abstract "Cross talk among different tissues and organs is a hotspot in metabolic research. Recent studies have revealed the regulatory roles of a number of myokines in metabolism. Here, we report that female mice lacking muscle-specific histone methylase G9a (Ehmt2Ckmm knockout [KO] or Ehmt2HSA KO) are resistant to high-fat diet (HFD)-induced obesity and hepatic steatosis. Furthermore, we identified a significantly upregulated circulating level of musclin, a myokine, in HFD-fed Ehmt2Ckmm KO or Ehmt2HSA KO female mice. Similarly, upregulated musclin was observed in mice injected with two structurally different inhibitors for G9a methylase activity: BIX01294 and A366. Moreover, injection of recombinant full-length musclin or its functional core domain inhibited the HFD-induced obesity and hepatic steatosis in wild-type female and male mice. Mechanistically, G9a methylase activity-dependently regulated muscular musclin level by binding to its promoter, also by regulating phosphorylated-FOXO1/FOXO1 levels in vivo and in vitro. Collectively, these data suggest a critical role for G9a in the muscle-liver-fat metabolic axis, at least for female mice. Musclin may serve as a potential therapeutic candidate for obesity and associated diseases." @default.
- W3090868074 created "2020-10-08" @default.
- W3090868074 creator A5000945121 @default.
- W3090868074 creator A5001348385 @default.
- W3090868074 creator A5032386151 @default.
- W3090868074 creator A5044910269 @default.
- W3090868074 creator A5045092668 @default.
- W3090868074 creator A5046946157 @default.
- W3090868074 creator A5047620686 @default.
- W3090868074 creator A5064530138 @default.
- W3090868074 creator A5071773009 @default.
- W3090868074 creator A5072315367 @default.
- W3090868074 date "2020-09-29" @default.
- W3090868074 modified "2023-10-16" @default.
- W3090868074 title "Muscular G9a Regulates Muscle-Liver-Fat Axis by Musclin Under Overnutrition in Female Mice" @default.
- W3090868074 cites W1893182892 @default.
- W3090868074 cites W1957997962 @default.
- W3090868074 cites W1978660434 @default.
- W3090868074 cites W1984540205 @default.
- W3090868074 cites W1995381409 @default.
- W3090868074 cites W1995895091 @default.
- W3090868074 cites W2005699094 @default.
- W3090868074 cites W2038496836 @default.
- W3090868074 cites W2046541342 @default.
- W3090868074 cites W2047208611 @default.
- W3090868074 cites W2052045659 @default.
- W3090868074 cites W2059347029 @default.
- W3090868074 cites W2059415816 @default.
- W3090868074 cites W2088924661 @default.
- W3090868074 cites W2092794927 @default.
- W3090868074 cites W2096528587 @default.
- W3090868074 cites W2117457995 @default.
- W3090868074 cites W2125164738 @default.
- W3090868074 cites W2128725121 @default.
- W3090868074 cites W2130350241 @default.
- W3090868074 cites W2140132617 @default.
- W3090868074 cites W2155658630 @default.
- W3090868074 cites W2163771097 @default.
- W3090868074 cites W2221507346 @default.
- W3090868074 cites W2324098470 @default.
- W3090868074 cites W2401055056 @default.
- W3090868074 cites W2519856267 @default.
- W3090868074 cites W2562967686 @default.
- W3090868074 cites W2586566042 @default.
- W3090868074 cites W2605110590 @default.
- W3090868074 cites W2606079720 @default.
- W3090868074 cites W2744462254 @default.
- W3090868074 cites W2750688577 @default.
- W3090868074 cites W2767092836 @default.
- W3090868074 cites W2771605046 @default.
- W3090868074 cites W2773542217 @default.
- W3090868074 cites W2972570161 @default.
- W3090868074 cites W2979643525 @default.
- W3090868074 cites W2980235029 @default.
- W3090868074 cites W3035517175 @default.
- W3090868074 doi "https://doi.org/10.2337/db20-0437" @default.
- W3090868074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32994276" @default.
- W3090868074 hasPublicationYear "2020" @default.
- W3090868074 type Work @default.
- W3090868074 sameAs 3090868074 @default.
- W3090868074 citedByCount "19" @default.
- W3090868074 countsByYear W30908680742021 @default.
- W3090868074 countsByYear W30908680742022 @default.
- W3090868074 countsByYear W30908680742023 @default.
- W3090868074 crossrefType "journal-article" @default.
- W3090868074 hasAuthorship W3090868074A5000945121 @default.
- W3090868074 hasAuthorship W3090868074A5001348385 @default.
- W3090868074 hasAuthorship W3090868074A5032386151 @default.
- W3090868074 hasAuthorship W3090868074A5044910269 @default.
- W3090868074 hasAuthorship W3090868074A5045092668 @default.
- W3090868074 hasAuthorship W3090868074A5046946157 @default.
- W3090868074 hasAuthorship W3090868074A5047620686 @default.
- W3090868074 hasAuthorship W3090868074A5064530138 @default.
- W3090868074 hasAuthorship W3090868074A5071773009 @default.
- W3090868074 hasAuthorship W3090868074A5072315367 @default.
- W3090868074 hasBestOaLocation W30908680741 @default.
- W3090868074 hasConcept C104317684 @default.
- W3090868074 hasConcept C117365660 @default.
- W3090868074 hasConcept C11960822 @default.
- W3090868074 hasConcept C126322002 @default.
- W3090868074 hasConcept C127561419 @default.
- W3090868074 hasConcept C134018914 @default.
- W3090868074 hasConcept C140149449 @default.
- W3090868074 hasConcept C170493617 @default.
- W3090868074 hasConcept C182704531 @default.
- W3090868074 hasConcept C2776175330 @default.
- W3090868074 hasConcept C2778302649 @default.
- W3090868074 hasConcept C2779959927 @default.
- W3090868074 hasConcept C511355011 @default.
- W3090868074 hasConcept C55493867 @default.
- W3090868074 hasConcept C71924100 @default.
- W3090868074 hasConcept C75217442 @default.
- W3090868074 hasConcept C86803240 @default.
- W3090868074 hasConcept C95444343 @default.
- W3090868074 hasConceptScore W3090868074C104317684 @default.
- W3090868074 hasConceptScore W3090868074C117365660 @default.
- W3090868074 hasConceptScore W3090868074C11960822 @default.
- W3090868074 hasConceptScore W3090868074C126322002 @default.