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- W3090883710 endingPage "112946" @default.
- W3090883710 startingPage "112946" @default.
- W3090883710 abstract "In this study, the phthalonitrile compound 4-(thieno[3,2-b]pyridin-7-yloxy] phthalonitrile (3), it’s peripherally tetra substituted zinc(II) (4) and magnesium(II) (5) phthalocyanines and their water-soluble derivatives (ZnPcQ) and (MgPcQ) were synthesized. The compounds were characterized with a combination of various spectroscopic techniques. The singlet oxygen quantum yields of ZnPcQ and MgPcQ were determined as 0.59 and 0.36. Their DNA nuclease, photodamage and oxidative photodamage experiments were investigated using agarose gel electrophoresis on supercoiled plasmid pBR322 DNA. The PDT effects of the compounds were investigated using MTT assay toward A549 cells. ZnPcQ and MgPcQ did not have damage effects on supercoiled plasmid pBR322 DNA without irradiation whereas ZnPcQ showed significant photodamage and oxidative photodamage effects upon irradiation. The photodamage mechanism experiments showed that singlet oxygen had a crucial role in the photodamage pathway. MgPcQ did not show considerable cytotoxic and phototoxic effects on A549 cell for 24 h. On the other hand, the cell viability of A549 was 69 ± 2.70 % at 10 μM without irradiation in the presence of ZnPcQ. A549 cells treated with 5 and 10 μM of ZnPcQ upon irradiation, A549 presented 75 ± 5.90 % and 44 ± 7.0 % of viabilities, respectively. These results suggested that ZnPcQ is a promising candidate for PDT and worthy of further research." @default.
- W3090883710 created "2020-10-08" @default.
- W3090883710 creator A5008182787 @default.
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- W3090883710 date "2021-01-01" @default.
- W3090883710 modified "2023-10-10" @default.
- W3090883710 title "The water soluble Zn(II) and Mg(II) phthalocyanines: Synthesis, photochemical, DNA photodamage and PDT effects against A549 cells" @default.
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- W3090883710 doi "https://doi.org/10.1016/j.jphotochem.2020.112946" @default.
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