FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090898192> ?p ?o ?g. }

• W3090898192 abstract "Summary Dendrites display a striking variety of neuronal type-specific morphologies, but the mechanisms and principles underlying such diversity remain elusive. A major player in defining the morphology of dendrites is the neuronal cytoskeleton, including evolutionarily conserved actin-modulatory proteins (AMPs). Still, we lack a clear understanding of how AMPs might support developmental phenomena such as neuron-type specific dendrite dynamics. To address precisely this level of in vivo specificity, we concentrated on a defined neuronal type, the class III dendritic arborisation (c3da) neuron of Drosophila larvae, displaying actin-enriched short terminal branchlets (STBs). Computational modelling reveals that the main branches of c3da neurons follow a general growth model based on optimal wiring, but the STBs do not. Instead, model STBs are defined by a short reach and a high affinity to grow towards the main branches. We thus concentrated on c3da STBs and developed new methods to quantitatively describe dendrite morphology and dynamics based on in vivo time-lapse imaging of mutants lacking individual AMPs. In this way, we extrapolated the role of these AMPs in defining STB properties. We propose that dendrite diversity is supported by the combination of a common step, refined by a neuron type-specific second level. For c3da neurons, we present a molecular model of how the combined action of multiple AMPs in vivo define the properties of these second level specialisations, the STBs. In brief A quantitative morphological dissection of the concerted actin-modulatory protein actions provides a model of dendrite branchlet outgrowth. Highlights Actin organisation in small terminal branchlets of Drosophila class III dendritic arborisation neurons Six actin-modulatory proteins individually control the characteristic morphology and dynamics of branchlets Quantitative tools for dendrite morphology and branch dynamics enable a comparative analysis A two-step computational growth model reproduces c3da dendrite morphology" @default.
• W3090898192 created "2020-10-08" @default.
• W3090898192 creator A5030072419 @default.
• W3090898192 creator A5059626898 @default.
• W3090898192 creator A5068735120 @default.
• W3090898192 creator A5069233268 @default.
• W3090898192 creator A5078297857 @default.
• W3090898192 date "2020-10-03" @default.
• W3090898192 modified "2023-09-26" @default.
• W3090898192 title "The branching code: a model of actin-driven dendrite arborisation" @default.
• W3090898192 cites W1529411207 @default.
• W3090898192 cites W1557656438 @default.
• W3090898192 cites W1834463603 @default.
• W3090898192 cites W1909620584 @default.
• W3090898192 cites W1963969404 @default.
• W3090898192 cites W1965210407 @default.
• W3090898192 cites W1967260735 @default.
• W3090898192 cites W1967596069 @default.
• W3090898192 cites W1976085780 @default.
• W3090898192 cites W1977650696 @default.
• W3090898192 cites W1979235369 @default.
• W3090898192 cites W1980361506 @default.
• W3090898192 cites W1980824787 @default.
• W3090898192 cites W1981383993 @default.
• W3090898192 cites W1981566818 @default.
• W3090898192 cites W1985384862 @default.
• W3090898192 cites W1986561157 @default.
• W3090898192 cites W1987338177 @default.
• W3090898192 cites W1990779469 @default.
• W3090898192 cites W1994034111 @default.
• W3090898192 cites W1997230083 @default.
• W3090898192 cites W2002577396 @default.
• W3090898192 cites W2022538678 @default.
• W3090898192 cites W2036018768 @default.
• W3090898192 cites W2038446297 @default.
• W3090898192 cites W2038761368 @default.
• W3090898192 cites W2047757962 @default.
• W3090898192 cites W2048092833 @default.
• W3090898192 cites W2049064952 @default.
• W3090898192 cites W2049494624 @default.
• W3090898192 cites W2050612706 @default.
• W3090898192 cites W2051370920 @default.
• W3090898192 cites W2055713200 @default.
• W3090898192 cites W2058293976 @default.
• W3090898192 cites W2064071063 @default.
• W3090898192 cites W2065943966 @default.
• W3090898192 cites W2066682953 @default.
• W3090898192 cites W2068954129 @default.
• W3090898192 cites W2070119451 @default.
• W3090898192 cites W2075966687 @default.
• W3090898192 cites W2076629935 @default.
• W3090898192 cites W2077489546 @default.
• W3090898192 cites W2087968048 @default.
• W3090898192 cites W2090109361 @default.
• W3090898192 cites W2091121637 @default.
• W3090898192 cites W2091512558 @default.
• W3090898192 cites W2094313061 @default.
• W3090898192 cites W2098173227 @default.
• W3090898192 cites W2099607192 @default.
• W3090898192 cites W2101565835 @default.
• W3090898192 cites W2103501363 @default.
• W3090898192 cites W2104206284 @default.
• W3090898192 cites W2105087111 @default.
• W3090898192 cites W2105315411 @default.
• W3090898192 cites W2106868006 @default.
• W3090898192 cites W2107756975 @default.
• W3090898192 cites W2110643873 @default.
• W3090898192 cites W2118038068 @default.
• W3090898192 cites W2118259897 @default.
• W3090898192 cites W2120446093 @default.
• W3090898192 cites W2124135702 @default.
• W3090898192 cites W2132739680 @default.
• W3090898192 cites W2133537045 @default.
• W3090898192 cites W2139969808 @default.
• W3090898192 cites W2142521845 @default.
• W3090898192 cites W2145595000 @default.
• W3090898192 cites W2148320506 @default.
• W3090898192 cites W2164614067 @default.
• W3090898192 cites W2166247014 @default.
• W3090898192 cites W2171895829 @default.
• W3090898192 cites W2198225484 @default.
• W3090898192 cites W2479561704 @default.
• W3090898192 cites W2508335446 @default.
• W3090898192 cites W2549056643 @default.
• W3090898192 cites W2589566967 @default.
• W3090898192 cites W2614818688 @default.
• W3090898192 cites W2626153556 @default.
• W3090898192 cites W2727776884 @default.
• W3090898192 cites W2728165324 @default.
• W3090898192 cites W2762172216 @default.
• W3090898192 cites W2766694055 @default.
• W3090898192 cites W2779756239 @default.
• W3090898192 cites W2794163195 @default.
• W3090898192 cites W2799647171 @default.
• W3090898192 cites W2883743649 @default.
• W3090898192 cites W2885764841 @default.
• W3090898192 cites W2901752080 @default.
• W3090898192 cites W2904021089 @default.
• W3090898192 cites W2911563640 @default.
• W3090898192 cites W2913699667 @default.

• next