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- W3090899587 abstract "The SELEX method and oligonucleotide combinatorial chemistry discovery process yields high- affinityyhigh-specificity ligands for virtually any molecular target. Typically, the enormous starting libraries used in the SELEXprocesscontain10 14 -10 15 sequences.Wenowaskifthe smaller sequences, complexity of extant organisms, and evo- lutionary history provide useful interactions between oligo- nucleotides and at least some unexpected targets. That is, do organisms contain a robust linkage map between their oligonucleotides and proteins andyor small molecules that enriches life? Wehaveacceptedthechallengeofwritinganinauguralarticle, hoping to stimulate and provoke other scientists to wonder with us about a chance to discover surprising molecular interactions in biology between nucleic acids and other intra- cellular components. We will chart the conceptual triangle surrounding in vitro evolution (the SELEX (for systematic evolution of ligands by exponential enrichment) methodolo- gy):insightsintotheprebioticearth,appliedmedicalresearch, and novel regulatory elements and circuits in cells (identified through the genomic SELEX process). We came to this set of ideasthroughthestudyofbacteriophageT4development,with a focus on translational regulation. It was that work and the extraordinary environment for RNA studies that exists at the University of Colorado in Boulder that led us to our present interests." @default.
- W3090899587 created "2020-10-08" @default.
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- W3090899587 date "1997-01-01" @default.
- W3090899587 modified "2023-09-26" @default.
- W3090899587 title "From oligonucleotide shapes to genomic SELEX: Novel biological regulatory loops" @default.
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- W3090899587 hasPublicationYear "1997" @default.
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