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- W3090993211 abstract "Fragile X syndrome (FXS) is the most common inherited source of intellectual disability in humans. FXS is caused by mutations that trigger epigenetic silencing of the Fmr1 gene. Loss of Fmr1 results in increased activity of the mitogen-activated protein kinase (MAPK) pathway. An important downstream consequence is activation of the mitogen-activated protein kinase interacting protein kinase (MNK). MNK phosphorylates the mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E). Excessive phosphorylation of eIF4E has been directly implicated in the cognitive and behavioral deficits associated with FXS. Pharmacological reduction of eIF4E phosphorylation is one potential strategy for FXS treatment. We demonstrate that systemic dosing of a highly specific, orally available MNK inhibitor, eFT508, attenuates numerous deficits associated with loss of Fmr1 in mice. eFT508 resolves a range of phenotypic abnormalities associated with FXS including macroorchidism, aberrant spinogenesis, and alterations in synaptic plasticity. Key behavioral deficits related to anxiety, social interaction, obsessive and repetitive activities, and object recognition are ameliorated by eFT508. Collectively, this work establishes eFT508 as a potential means to reverse deficits associated with FXS." @default.
- W3090993211 created "2020-10-08" @default.
- W3090993211 creator A5009623770 @default.
- W3090993211 creator A5048496766 @default.
- W3090993211 creator A5051317898 @default.
- W3090993211 creator A5055560182 @default.
- W3090993211 creator A5072719797 @default.
- W3090993211 creator A5073757884 @default.
- W3090993211 creator A5075615241 @default.
- W3090993211 creator A5083313377 @default.
- W3090993211 date "2020-10-01" @default.
- W3090993211 modified "2023-09-26" @default.
- W3090993211 title "A Highly Selective MNK Inhibitor Rescues Deficits Associated with Fragile X Syndrome in Mice" @default.
- W3090993211 cites W1012020936 @default.
- W3090993211 cites W1535975452 @default.
- W3090993211 cites W1551673807 @default.
- W3090993211 cites W156771624 @default.
- W3090993211 cites W1642338065 @default.
- W3090993211 cites W1953215256 @default.
- W3090993211 cites W1978236923 @default.
- W3090993211 cites W1994017777 @default.
- W3090993211 cites W2001090500 @default.
- W3090993211 cites W2004311949 @default.
- W3090993211 cites W2004342279 @default.
- W3090993211 cites W2023366466 @default.
- W3090993211 cites W2024287181 @default.
- W3090993211 cites W2025500109 @default.
- W3090993211 cites W2026402282 @default.
- W3090993211 cites W2029637282 @default.
- W3090993211 cites W2031785254 @default.
- W3090993211 cites W2043335534 @default.
- W3090993211 cites W2047636274 @default.
- W3090993211 cites W2052326665 @default.
- W3090993211 cites W2053112623 @default.
- W3090993211 cites W2053304186 @default.
- W3090993211 cites W2060340275 @default.
- W3090993211 cites W2063791461 @default.
- W3090993211 cites W2068065584 @default.
- W3090993211 cites W2075344525 @default.
- W3090993211 cites W2076567960 @default.
- W3090993211 cites W2082078122 @default.
- W3090993211 cites W2083945553 @default.
- W3090993211 cites W2089927164 @default.
- W3090993211 cites W2090478385 @default.
- W3090993211 cites W2091601808 @default.
- W3090993211 cites W2092491372 @default.
- W3090993211 cites W2093802594 @default.
- W3090993211 cites W2096184369 @default.
- W3090993211 cites W2096444933 @default.
- W3090993211 cites W2098756736 @default.
- W3090993211 cites W2099545905 @default.
- W3090993211 cites W2100468603 @default.
- W3090993211 cites W2105020148 @default.
- W3090993211 cites W2110811750 @default.
- W3090993211 cites W2110871941 @default.
- W3090993211 cites W2111414408 @default.
- W3090993211 cites W2112013596 @default.
- W3090993211 cites W2116190619 @default.
- W3090993211 cites W2116276594 @default.
- W3090993211 cites W2121647526 @default.
- W3090993211 cites W2123708266 @default.
- W3090993211 cites W2126656381 @default.
- W3090993211 cites W2130431667 @default.
- W3090993211 cites W2131956972 @default.
- W3090993211 cites W2132943956 @default.
- W3090993211 cites W2133291891 @default.
- W3090993211 cites W2138144699 @default.
- W3090993211 cites W2140254301 @default.
- W3090993211 cites W2147050348 @default.
- W3090993211 cites W2147609603 @default.
- W3090993211 cites W2149919973 @default.
- W3090993211 cites W2151299944 @default.
- W3090993211 cites W2152268460 @default.
- W3090993211 cites W2154391980 @default.
- W3090993211 cites W2156319664 @default.
- W3090993211 cites W2157497892 @default.
- W3090993211 cites W2158323020 @default.
- W3090993211 cites W2158777452 @default.
- W3090993211 cites W2159063290 @default.
- W3090993211 cites W2162775240 @default.
- W3090993211 cites W2164882663 @default.
- W3090993211 cites W2168221097 @default.
- W3090993211 cites W2321319950 @default.
- W3090993211 cites W2467262680 @default.
- W3090993211 cites W2584428552 @default.
- W3090993211 cites W2615129326 @default.
- W3090993211 cites W2727220925 @default.
- W3090993211 cites W2736437089 @default.
- W3090993211 cites W2738288379 @default.
- W3090993211 cites W2741781756 @default.
- W3090993211 cites W2766431378 @default.
- W3090993211 cites W2767324723 @default.
- W3090993211 cites W2769758347 @default.
- W3090993211 cites W2772067948 @default.
- W3090993211 cites W2781399842 @default.
- W3090993211 cites W2785091002 @default.
- W3090993211 cites W2791211198 @default.
- W3090993211 cites W2797244528 @default.