Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090997340> ?p ?o ?g. }
- W3090997340 endingPage "108860" @default.
- W3090997340 startingPage "108860" @default.
- W3090997340 abstract "• PRV protein kinase, UL13, inhibits the IFN-β signaling pathway by targeting IRF3. • UL13-null PRV is impaired in its ability to retard IRF3 and IFN-β expression in cells. • UL13-null PRV’s pathogenicity is significantly less than wild-type PRV in mice. Pseudorabies virus (PRV), a porcine alphaherpesvirus, causes neurological disorders and reproductive failure in swine. It is capable of avoiding host antiviral responses, resulting in viral latency in infected animals. The mechanisms by which many PRV proteins help the virus to evade immune surveillance are poorly understood. In this study, we found that the PRV protein kinase, UL13, inhibits the IFN-β signaling pathway by targeting interferon regulatory factor 3 (IRF3) for ubiquitination and degradation. PRV with mutant of UL13 is impaired in its ability to hinder IRF3 and interferon-β (IFN-β) activation, and has significantly less pathogenesis in mice that wild-type PRV. Our findings reveal an as yet undescribed mechanism utilized by PRV to evade host immune responses. PRV UL13 is a potential target for attenuated vaccines and antiviral drugs." @default.
- W3090997340 created "2020-10-08" @default.
- W3090997340 creator A5005602487 @default.
- W3090997340 creator A5019383992 @default.
- W3090997340 creator A5030929816 @default.
- W3090997340 creator A5046668761 @default.
- W3090997340 creator A5062319124 @default.
- W3090997340 creator A5065817691 @default.
- W3090997340 creator A5073313773 @default.
- W3090997340 creator A5084705624 @default.
- W3090997340 date "2020-11-01" @default.
- W3090997340 modified "2023-10-10" @default.
- W3090997340 title "PRV-encoded UL13 protein kinase acts as an antagonist of innate immunity by targeting IRF3-signaling pathways" @default.
- W3090997340 cites W1964440626 @default.
- W3090997340 cites W1987334631 @default.
- W3090997340 cites W1994647589 @default.
- W3090997340 cites W2000177767 @default.
- W3090997340 cites W2008458519 @default.
- W3090997340 cites W2036436901 @default.
- W3090997340 cites W2058015620 @default.
- W3090997340 cites W2067706259 @default.
- W3090997340 cites W2073004070 @default.
- W3090997340 cites W2074003791 @default.
- W3090997340 cites W2078490133 @default.
- W3090997340 cites W2081563789 @default.
- W3090997340 cites W2089297912 @default.
- W3090997340 cites W2090223302 @default.
- W3090997340 cites W2097504031 @default.
- W3090997340 cites W2097895173 @default.
- W3090997340 cites W2113210730 @default.
- W3090997340 cites W2114085082 @default.
- W3090997340 cites W2115616959 @default.
- W3090997340 cites W2118225942 @default.
- W3090997340 cites W2121266203 @default.
- W3090997340 cites W2122880566 @default.
- W3090997340 cites W2144787399 @default.
- W3090997340 cites W2160434954 @default.
- W3090997340 cites W2164239618 @default.
- W3090997340 cites W2293157603 @default.
- W3090997340 cites W2477973757 @default.
- W3090997340 cites W2521402386 @default.
- W3090997340 cites W2525002693 @default.
- W3090997340 cites W2584377636 @default.
- W3090997340 cites W2734714222 @default.
- W3090997340 cites W2751444857 @default.
- W3090997340 cites W2800868935 @default.
- W3090997340 cites W2913157791 @default.
- W3090997340 cites W2921248996 @default.
- W3090997340 cites W2939067693 @default.
- W3090997340 cites W2952818759 @default.
- W3090997340 cites W2973725957 @default.
- W3090997340 cites W2998340370 @default.
- W3090997340 cites W3036881409 @default.
- W3090997340 cites W620025267 @default.
- W3090997340 cites W793353277 @default.
- W3090997340 doi "https://doi.org/10.1016/j.vetmic.2020.108860" @default.
- W3090997340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33045632" @default.
- W3090997340 hasPublicationYear "2020" @default.
- W3090997340 type Work @default.
- W3090997340 sameAs 3090997340 @default.
- W3090997340 citedByCount "21" @default.
- W3090997340 countsByYear W30909973402021 @default.
- W3090997340 countsByYear W30909973402022 @default.
- W3090997340 countsByYear W30909973402023 @default.
- W3090997340 crossrefType "journal-article" @default.
- W3090997340 hasAuthorship W3090997340A5005602487 @default.
- W3090997340 hasAuthorship W3090997340A5019383992 @default.
- W3090997340 hasAuthorship W3090997340A5030929816 @default.
- W3090997340 hasAuthorship W3090997340A5046668761 @default.
- W3090997340 hasAuthorship W3090997340A5062319124 @default.
- W3090997340 hasAuthorship W3090997340A5065817691 @default.
- W3090997340 hasAuthorship W3090997340A5073313773 @default.
- W3090997340 hasAuthorship W3090997340A5084705624 @default.
- W3090997340 hasConcept C104317684 @default.
- W3090997340 hasConcept C136449434 @default.
- W3090997340 hasConcept C137361374 @default.
- W3090997340 hasConcept C156155473 @default.
- W3090997340 hasConcept C159047783 @default.
- W3090997340 hasConcept C161238802 @default.
- W3090997340 hasConcept C184235292 @default.
- W3090997340 hasConcept C203014093 @default.
- W3090997340 hasConcept C2522874641 @default.
- W3090997340 hasConcept C25602115 @default.
- W3090997340 hasConcept C2776178377 @default.
- W3090997340 hasConcept C2776966659 @default.
- W3090997340 hasConcept C2778278966 @default.
- W3090997340 hasConcept C2780209191 @default.
- W3090997340 hasConcept C2780718723 @default.
- W3090997340 hasConcept C54355233 @default.
- W3090997340 hasConcept C62478195 @default.
- W3090997340 hasConcept C86803240 @default.
- W3090997340 hasConcept C8891405 @default.
- W3090997340 hasConcept C90934575 @default.
- W3090997340 hasConcept C9173399 @default.
- W3090997340 hasConcept C95444343 @default.
- W3090997340 hasConcept C97029542 @default.
- W3090997340 hasConceptScore W3090997340C104317684 @default.
- W3090997340 hasConceptScore W3090997340C136449434 @default.