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• W3091056871 abstract "Abstract Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in the striatum that express D 1 and D 2 receptors respectively. The spinal cord also expresses all dopamine receptors; however, how the specific receptors regulate spinal network output in mammals is poorly understood. We explore the receptor-specific mechanisms that underlie dopaminergic control of spinal network output of neonatal mice during changes in spinal network excitability. During spontaneous activity, which is a characteristic of developing spinal networks operating in a low excitability state, we found that dopamine is primarily inhibitory. We uncover an excitatory D 1 -mediated effect of dopamine on motoneurons and network output that also involves co-activation with D 2 receptors. Critically, these excitatory actions require higher concentrations of dopamine; however, analysis of dopamine concentrations of neonates indicates that endogenous levels of spinal dopamine are low. Because endogenous levels of spinal dopamine are low, this excitatory dopaminergic pathway is likely physiologically-silent at this stage in development. In contrast, the inhibitory effect of dopamine, at low physiological concentrations is mediated by parallel activation of D 2 , D 3 , D 4 and α 2 receptors which is reproduced when endogenous dopamine levels are increased by blocking dopamine reuptake and metabolism. We provide evidence in support of dedicated spinal network components that are controlled by excitatory D 1 and inhibitory D 2 receptors that is reminiscent of the classic dopaminergic indirect and direct pathway within the striatum. These results indicate that network state is an important factor that dictates receptor-specific and therefore dose-dependent control of neuromodulators on spinal network output and advances our understanding of how neuromodulators regulate neural networks under dynamically changing excitability." @default.
• W3091056871 created "2020-10-08" @default.
• W3091056871 creator A5007034989 @default.
• W3091056871 creator A5026087366 @default.
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• W3091056871 creator A5088133722 @default.
• W3091056871 creator A5088403251 @default.
• W3091056871 date "2020-10-02" @default.
• W3091056871 modified "2023-10-15" @default.
• W3091056871 title "A dynamic role for dopamine receptors in the control of mammalian spinal networks" @default.
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