Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091063752> ?p ?o ?g. }
- W3091063752 endingPage "290" @default.
- W3091063752 startingPage "281" @default.
- W3091063752 abstract "Mutations in the highly similar genes B-cell translocation gene 1 (BTG1) and BTG2 are identified in approximately 10-15% of non-Hodgkin lymphoma cases, which may suggest a direct involvement of BTG1 and BTG2 in malignant transformation. However, it is unclear whether or how disease-associated mutations impair the function of these genes. Therefore, we selected 16 BTG1 variants based on in silico analysis. We then evaluated (i) the ability of these variants to interact with the known protein-binding partners CNOT7 and CNOT8, which encode the Caf1 catalytic subunit of the Ccr4-Not deadenylase complex; (ii) the activity of the variant proteins in cell cycle progression; (iii) translational repression; and (iv) mRNA degradation. Based on these analyses, we conclude that mutations in BTG1 may contribute to malignant transformation and tumor cell proliferation by interfering with its anti-proliferative activity and ability to interact with CNOT7 and CNOT8." @default.
- W3091063752 created "2020-10-08" @default.
- W3091063752 creator A5008886411 @default.
- W3091063752 creator A5019948801 @default.
- W3091063752 creator A5062804656 @default.
- W3091063752 creator A5082869226 @default.
- W3091063752 date "2020-10-06" @default.
- W3091063752 modified "2023-10-17" @default.
- W3091063752 title "Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4–Not deadenylase in non-Hodgkin lymphoma" @default.
- W3091063752 cites W1523373234 @default.
- W3091063752 cites W1533371356 @default.
- W3091063752 cites W1803102843 @default.
- W3091063752 cites W1973307489 @default.
- W3091063752 cites W1980093005 @default.
- W3091063752 cites W1980740976 @default.
- W3091063752 cites W1989773675 @default.
- W3091063752 cites W1996757904 @default.
- W3091063752 cites W2003262666 @default.
- W3091063752 cites W2006680755 @default.
- W3091063752 cites W2014876153 @default.
- W3091063752 cites W2015782236 @default.
- W3091063752 cites W2022832110 @default.
- W3091063752 cites W2028468783 @default.
- W3091063752 cites W2033275544 @default.
- W3091063752 cites W2043317321 @default.
- W3091063752 cites W2045750237 @default.
- W3091063752 cites W2061034039 @default.
- W3091063752 cites W2062290101 @default.
- W3091063752 cites W2063896920 @default.
- W3091063752 cites W2065397600 @default.
- W3091063752 cites W2068362658 @default.
- W3091063752 cites W2068435470 @default.
- W3091063752 cites W2073582993 @default.
- W3091063752 cites W2077077203 @default.
- W3091063752 cites W2085206746 @default.
- W3091063752 cites W2090314062 @default.
- W3091063752 cites W2104148121 @default.
- W3091063752 cites W2104865601 @default.
- W3091063752 cites W2122509443 @default.
- W3091063752 cites W2128859075 @default.
- W3091063752 cites W2129174269 @default.
- W3091063752 cites W2142258451 @default.
- W3091063752 cites W2145853549 @default.
- W3091063752 cites W2152720366 @default.
- W3091063752 cites W2158102062 @default.
- W3091063752 cites W2166337170 @default.
- W3091063752 cites W2170744835 @default.
- W3091063752 cites W2181388594 @default.
- W3091063752 cites W2265308074 @default.
- W3091063752 cites W2277148392 @default.
- W3091063752 cites W2326766364 @default.
- W3091063752 cites W2517775816 @default.
- W3091063752 cites W2755691725 @default.
- W3091063752 cites W2762450632 @default.
- W3091063752 cites W2763397143 @default.
- W3091063752 cites W2897411414 @default.
- W3091063752 cites W2900925811 @default.
- W3091063752 doi "https://doi.org/10.1080/10428194.2020.1827243" @default.
- W3091063752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33021411" @default.
- W3091063752 hasPublicationYear "2020" @default.
- W3091063752 type Work @default.
- W3091063752 sameAs 3091063752 @default.
- W3091063752 citedByCount "8" @default.
- W3091063752 countsByYear W30910637522021 @default.
- W3091063752 countsByYear W30910637522022 @default.
- W3091063752 countsByYear W30910637522023 @default.
- W3091063752 crossrefType "journal-article" @default.
- W3091063752 hasAuthorship W3091063752A5008886411 @default.
- W3091063752 hasAuthorship W3091063752A5019948801 @default.
- W3091063752 hasAuthorship W3091063752A5062804656 @default.
- W3091063752 hasAuthorship W3091063752A5082869226 @default.
- W3091063752 hasBestOaLocation W30910637522 @default.
- W3091063752 hasConcept C104292427 @default.
- W3091063752 hasConcept C104317684 @default.
- W3091063752 hasConcept C138626823 @default.
- W3091063752 hasConcept C1491633281 @default.
- W3091063752 hasConcept C203014093 @default.
- W3091063752 hasConcept C2775905019 @default.
- W3091063752 hasConcept C2779338263 @default.
- W3091063752 hasConcept C29537977 @default.
- W3091063752 hasConcept C501734568 @default.
- W3091063752 hasConcept C502942594 @default.
- W3091063752 hasConcept C54355233 @default.
- W3091063752 hasConcept C62112901 @default.
- W3091063752 hasConcept C86803240 @default.
- W3091063752 hasConceptScore W3091063752C104292427 @default.
- W3091063752 hasConceptScore W3091063752C104317684 @default.
- W3091063752 hasConceptScore W3091063752C138626823 @default.
- W3091063752 hasConceptScore W3091063752C1491633281 @default.
- W3091063752 hasConceptScore W3091063752C203014093 @default.
- W3091063752 hasConceptScore W3091063752C2775905019 @default.
- W3091063752 hasConceptScore W3091063752C2779338263 @default.
- W3091063752 hasConceptScore W3091063752C29537977 @default.
- W3091063752 hasConceptScore W3091063752C501734568 @default.
- W3091063752 hasConceptScore W3091063752C502942594 @default.
- W3091063752 hasConceptScore W3091063752C54355233 @default.
- W3091063752 hasConceptScore W3091063752C62112901 @default.
- W3091063752 hasConceptScore W3091063752C86803240 @default.