Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091097189> ?p ?o ?g. }
- W3091097189 endingPage "7794" @default.
- W3091097189 startingPage "7794" @default.
- W3091097189 abstract "Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds. PRP therapy is based on the fact that platelet growth factors (PGFs) support the three phases of wound healing and repair cascade (inflammation, proliferation, remodeling). Many different PRP formulations have been evaluated, originating from human, in vitro, and animal studies. However, recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, progress has been made in understanding PRP technology and the concepts for bioformulation, and new research directives and new indications have been suggested. In this review, we will discuss recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects, and pain killing. Furthermore, we discuss PRP mechanisms related to inflammation and angiogenesis in tissue repair and regenerative processes. Lastly, we will review the effect of certain drugs on PRP activity, and the combination of PRP and rehabilitation protocols." @default.
- W3091097189 created "2020-10-08" @default.
- W3091097189 creator A5002682191 @default.
- W3091097189 creator A5023869713 @default.
- W3091097189 creator A5042200894 @default.
- W3091097189 creator A5042922584 @default.
- W3091097189 creator A5047458376 @default.
- W3091097189 date "2020-10-21" @default.
- W3091097189 modified "2023-10-10" @default.
- W3091097189 title "Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020" @default.
- W3091097189 cites W1498390101 @default.
- W3091097189 cites W1518095394 @default.
- W3091097189 cites W1554736362 @default.
- W3091097189 cites W1561516029 @default.
- W3091097189 cites W1577428593 @default.
- W3091097189 cites W1596733714 @default.
- W3091097189 cites W1605478240 @default.
- W3091097189 cites W1965412752 @default.
- W3091097189 cites W1967956876 @default.
- W3091097189 cites W1969426171 @default.
- W3091097189 cites W1975162216 @default.
- W3091097189 cites W1976427377 @default.
- W3091097189 cites W1976954262 @default.
- W3091097189 cites W1981688423 @default.
- W3091097189 cites W1983997309 @default.
- W3091097189 cites W1986282241 @default.
- W3091097189 cites W1990341278 @default.
- W3091097189 cites W1990928424 @default.
- W3091097189 cites W1992411507 @default.
- W3091097189 cites W1998229370 @default.
- W3091097189 cites W2001267592 @default.
- W3091097189 cites W2004805241 @default.
- W3091097189 cites W2006113857 @default.
- W3091097189 cites W2008144172 @default.
- W3091097189 cites W2011008206 @default.
- W3091097189 cites W2012680181 @default.
- W3091097189 cites W2013518981 @default.
- W3091097189 cites W2014080590 @default.
- W3091097189 cites W2020482390 @default.
- W3091097189 cites W2026254409 @default.
- W3091097189 cites W2026277675 @default.
- W3091097189 cites W2028370526 @default.
- W3091097189 cites W2030012902 @default.
- W3091097189 cites W2030322516 @default.
- W3091097189 cites W2033967818 @default.
- W3091097189 cites W2036062643 @default.
- W3091097189 cites W2036563673 @default.
- W3091097189 cites W2037905113 @default.
- W3091097189 cites W2038043933 @default.
- W3091097189 cites W2043647716 @default.
- W3091097189 cites W2044159907 @default.
- W3091097189 cites W2048051165 @default.
- W3091097189 cites W2048219618 @default.
- W3091097189 cites W2050701385 @default.
- W3091097189 cites W2056332475 @default.
- W3091097189 cites W2060945377 @default.
- W3091097189 cites W2063048290 @default.
- W3091097189 cites W2063570212 @default.
- W3091097189 cites W2066496557 @default.
- W3091097189 cites W2069786094 @default.
- W3091097189 cites W2069794089 @default.
- W3091097189 cites W2070037324 @default.
- W3091097189 cites W2074716378 @default.
- W3091097189 cites W2084088575 @default.
- W3091097189 cites W2089573422 @default.
- W3091097189 cites W2089878334 @default.
- W3091097189 cites W2091150362 @default.
- W3091097189 cites W2091637866 @default.
- W3091097189 cites W2091854627 @default.
- W3091097189 cites W2094326057 @default.
- W3091097189 cites W2098153182 @default.
- W3091097189 cites W2098799479 @default.
- W3091097189 cites W2101828708 @default.
- W3091097189 cites W2102461113 @default.
- W3091097189 cites W2102895306 @default.
- W3091097189 cites W2103214221 @default.
- W3091097189 cites W2105593496 @default.
- W3091097189 cites W2110146409 @default.
- W3091097189 cites W2110315161 @default.
- W3091097189 cites W2113345919 @default.
- W3091097189 cites W2114587449 @default.
- W3091097189 cites W2115852450 @default.
- W3091097189 cites W2116500923 @default.
- W3091097189 cites W2121620043 @default.
- W3091097189 cites W2122355138 @default.
- W3091097189 cites W2123220183 @default.
- W3091097189 cites W2123270129 @default.
- W3091097189 cites W2124956214 @default.
- W3091097189 cites W2125677500 @default.
- W3091097189 cites W2127845947 @default.
- W3091097189 cites W2128807350 @default.
- W3091097189 cites W2128814992 @default.
- W3091097189 cites W2129290564 @default.
- W3091097189 cites W2130458932 @default.
- W3091097189 cites W2130679926 @default.
- W3091097189 cites W2131165482 @default.
- W3091097189 cites W2132822330 @default.
- W3091097189 cites W2134057773 @default.