FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091111808> ?p ?o ?g. }

• W3091111808 endingPage "128" @default.
• W3091111808 startingPage "119" @default.
• W3091111808 abstract "Abstract Clinicopathological evidence supports endometrial atypical hyperplasia (AH) or endometrial intraepithelial neoplasia as the precursor of uterine endometrioid carcinoma (EC), the most common gynecologic malignancy. However, the pathogenic progression from AH to EC remains unclear. Here, we employed whole‐exome sequencing to identify somatic mutations and copy number changes in micro‐dissected lesions from 30 pairs of newly diagnosed AH and EC. We found that all but one pair of AHs shared the same DNA mismatch repair status as their corresponding ECs. The percentage of common mutations between AH lesions and corresponding ECs varied significantly, ranging from 0.1% to 82%. Microsatellite stable AHs had fewer cancer driver mutations than ECs (5 versus 7, p = 0.017), but among microsatellite unstable AHs and ECs there was no difference in mutational numbers (36 versus 38, p = 0.65). As compared to AH specimens, 19 (79%) of 24 microsatellite stable EC tumors gained new cancer driver mutations, most of which involved PTEN , ARID1A , PIK3CA , CTNNB1 , or CHD4 . Our results suggest that some AH lesions are the immediate precursor of ECs, and progression depends on acquisition of additional cancer driver mutations. However, a complex clonal relationship between AH and EC can also be appreciated, as in some cases both lesions diverge very early or arise independently, thus co‐developing with distinct genetic trajectories. Our genome‐wide profile of mutations in AH and EC shines new light on the molecular landscape of tumor progression. © 2020 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
• W3091111808 created "2020-10-08" @default.
• W3091111808 creator A5002650738 @default.
• W3091111808 creator A5014887786 @default.
• W3091111808 creator A5019250137 @default.
• W3091111808 creator A5037870558 @default.
• W3091111808 creator A5039289212 @default.
• W3091111808 creator A5050465341 @default.
• W3091111808 creator A5056495741 @default.
• W3091111808 creator A5063284671 @default.
• W3091111808 creator A5072217426 @default.
• W3091111808 creator A5080848710 @default.
• W3091111808 creator A5083629138 @default.
• W3091111808 creator A5091120394 @default.
• W3091111808 date "2020-11-13" @default.
• W3091111808 modified "2023-10-05" @default.
• W3091111808 title "Genome‐wide mutation analysis in precancerous lesions of endometrial carcinoma" @default.
• W3091111808 cites W1507577134 @default.
• W3091111808 cites W1980959075 @default.
• W3091111808 cites W2009350168 @default.
• W3091111808 cites W2011363925 @default.
• W3091111808 cites W2019905528 @default.
• W3091111808 cites W2021341670 @default.
• W3091111808 cites W2024827041 @default.
• W3091111808 cites W2041440766 @default.
• W3091111808 cites W2042677597 @default.
• W3091111808 cites W2043402452 @default.
• W3091111808 cites W2044873007 @default.
• W3091111808 cites W2093953774 @default.
• W3091111808 cites W2095881173 @default.
• W3091111808 cites W2097113048 @default.
• W3091111808 cites W2097665491 @default.
• W3091111808 cites W2102108020 @default.
• W3091111808 cites W2123016804 @default.
• W3091111808 cites W2135109253 @default.
• W3091111808 cites W2157835144 @default.
• W3091111808 cites W2392679799 @default.
• W3091111808 cites W2584993633 @default.
• W3091111808 cites W2734453503 @default.
• W3091111808 cites W2765952964 @default.
• W3091111808 cites W2789811819 @default.
• W3091111808 cites W2794566242 @default.
• W3091111808 cites W2797268891 @default.
• W3091111808 cites W2810180277 @default.
• W3091111808 cites W2899144445 @default.
• W3091111808 cites W2902566714 @default.
• W3091111808 cites W2904746252 @default.
• W3091111808 cites W2905518067 @default.
• W3091111808 cites W2907505155 @default.
• W3091111808 cites W2911188335 @default.
• W3091111808 cites W2915587043 @default.
• W3091111808 cites W2921362750 @default.
• W3091111808 cites W2922661027 @default.
• W3091111808 cites W2938413645 @default.
• W3091111808 cites W2990278530 @default.
• W3091111808 cites W3030510713 @default.
• W3091111808 cites W4211224662 @default.
• W3091111808 doi "https://doi.org/10.1002/path.5566" @default.
• W3091111808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33016334" @default.
• W3091111808 hasPublicationYear "2020" @default.
• W3091111808 type Work @default.
• W3091111808 sameAs 3091111808 @default.
• W3091111808 citedByCount "24" @default.
• W3091111808 countsByYear W30911118082020 @default.
• W3091111808 countsByYear W30911118082021 @default.
• W3091111808 countsByYear W30911118082022 @default.
• W3091111808 countsByYear W30911118082023 @default.
• W3091111808 crossrefType "journal-article" @default.
• W3091111808 hasAuthorship W3091111808A5002650738 @default.
• W3091111808 hasAuthorship W3091111808A5014887786 @default.
• W3091111808 hasAuthorship W3091111808A5019250137 @default.
• W3091111808 hasAuthorship W3091111808A5037870558 @default.
• W3091111808 hasAuthorship W3091111808A5039289212 @default.
• W3091111808 hasAuthorship W3091111808A5050465341 @default.
• W3091111808 hasAuthorship W3091111808A5056495741 @default.
• W3091111808 hasAuthorship W3091111808A5063284671 @default.
• W3091111808 hasAuthorship W3091111808A5072217426 @default.
• W3091111808 hasAuthorship W3091111808A5080848710 @default.
• W3091111808 hasAuthorship W3091111808A5083629138 @default.
• W3091111808 hasAuthorship W3091111808A5091120394 @default.
• W3091111808 hasConcept C104317684 @default.
• W3091111808 hasConcept C121608353 @default.
• W3091111808 hasConcept C16671776 @default.
• W3091111808 hasConcept C180754005 @default.
• W3091111808 hasConcept C190283241 @default.
• W3091111808 hasConcept C2775904963 @default.
• W3091111808 hasConcept C2777088508 @default.
• W3091111808 hasConcept C2777546739 @default.
• W3091111808 hasConcept C2777609662 @default.
• W3091111808 hasConcept C2779256057 @default.
• W3091111808 hasConcept C2779399171 @default.
• W3091111808 hasConcept C2779767149 @default.
• W3091111808 hasConcept C501734568 @default.
• W3091111808 hasConcept C502942594 @default.
• W3091111808 hasConcept C54355233 @default.
• W3091111808 hasConcept C61320498 @default.
• W3091111808 hasConcept C86554907 @default.
• W3091111808 hasConcept C86803240 @default.

• next