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• W3091121189 abstract "– COVID-19 caused by SARS-CoV-2 leads to myriad range of organ involvement including liver dysfunction. To analyse the liver function in patients with COVID-19 and their association with respect to age, sex, severity of disease and clinical features. This study was a cross-sectional study done at Rajendra Institute of Medical Sciences, Ranchi. 91 patients admitted with confirmed SARS-CoV-2 infection were included in this study and divided into asymptomatic, mild, moderate and severe groups. Liver function tests were compared among different severity groups. Of 91 patients with COVID-19, 70 (76.9%) had abnormal liver function. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin levels was 1–2 × ULN in 33(36.3%), 34(37.3%), 12(13.2%), 6(6.6%) cases and >2 × ULN in 20(22%), 18(19.8%), 7(7.7%) and 2 (2.2%) cases respectively. Mean AST and ALP levels among different severity groups of COVID-19 was statistically significant (p < 0.05) whereas mean ALT and total bilirubin levels was statistically non-significant (p > 0.05). There was no statistical difference between males and females with regard to abnormal liver function. Liver injury was seen in 64.3% cases of hypertension and 73.3% cases of diabetes. Fever, myalgia, headache and breathlessness were found to be correlated significantly with severity of disease. Liver injury is common in SARS-CoV-2 infection and is more prevalent in the severe disease group. Aspartate transaminase and alkaline phosphatase are better indicators of covid-19 induced liver injury than alanine transaminase and total bilirubin." @default.
• W3091121189 created "2020-10-08" @default.
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• W3091121189 date "2020-11-01" @default.
• W3091121189 modified "2023-10-17" @default.
• W3091121189 title "Pattern of liver function and clinical profile in COVID-19: A cross-sectional study of 91 patients" @default.
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• W3091121189 doi "https://doi.org/10.1016/j.dsx.2020.10.001" @default.
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