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- W3091172233 abstract "The extracellular matrix (ECM) is a fundamental component of multicellular organisms that orchestrates developmental processes and controls cell and tissue organization. We previously identified the novel ECM protein SNED1 as a promoter of breast cancer metastasis and showed that its level of expression negatively correlated with breast cancer patient survival. Here, we sought to identify the roles of SNED1 during murine development.We generated two novel Sned1 knockout mouse strains and showed that Sned1 is essential since homozygous ablation of the gene led to early neonatal lethality. Phenotypic analysis of the surviving knockout mice revealed a role for SNED1 in the development of craniofacial and skeletal structures since Sned1 knockout resulted in growth defects, nasal cavity occlusion, and craniofacial malformations. Sned1 is widely expressed in embryos, notably by cell populations undergoing epithelial-to-mesenchymal transition, such as the neural crest cells. We further show that mice with a neural-crest-cell-specific deletion of Sned1 survive, but display facial anomalies partly phenocopying the global knockout mice.Our results demonstrate requisite roles for SNED1 during development and neonatal survival. Importantly, the deletion of 2q37.3 in humans, a region that includes the SNED1 locus, has been associated with facial dysmorphism and short stature." @default.
- W3091172233 created "2020-10-08" @default.
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- W3091172233 date "2020-10-22" @default.
- W3091172233 modified "2023-10-17" @default.
- W3091172233 title "Knockout of the gene encoding the extracellular matrix protein <scp>SNED1</scp> results in early neonatal lethality and craniofacial malformations" @default.
- W3091172233 cites W1515359463 @default.
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- W3091172233 cites W1835943580 @default.
- W3091172233 cites W189486514 @default.
- W3091172233 cites W1944035943 @default.
- W3091172233 cites W1964081206 @default.
- W3091172233 cites W1965498876 @default.
- W3091172233 cites W1966857509 @default.
- W3091172233 cites W1975513365 @default.
- W3091172233 cites W1976671705 @default.
- W3091172233 cites W1978772117 @default.
- W3091172233 cites W1980537277 @default.
- W3091172233 cites W1984532877 @default.
- W3091172233 cites W1986504460 @default.
- W3091172233 cites W1988692408 @default.
- W3091172233 cites W1999132074 @default.
- W3091172233 cites W2004622806 @default.
- W3091172233 cites W2016901545 @default.
- W3091172233 cites W2026616100 @default.
- W3091172233 cites W2026757955 @default.
- W3091172233 cites W2028745546 @default.
- W3091172233 cites W2031897866 @default.
- W3091172233 cites W2043880350 @default.
- W3091172233 cites W2049470741 @default.
- W3091172233 cites W2050014442 @default.
- W3091172233 cites W2053699349 @default.
- W3091172233 cites W2057280155 @default.
- W3091172233 cites W2061712143 @default.
- W3091172233 cites W2064368262 @default.
- W3091172233 cites W2074169344 @default.
- W3091172233 cites W2078586977 @default.
- W3091172233 cites W2080743718 @default.
- W3091172233 cites W2082914950 @default.
- W3091172233 cites W2085544097 @default.
- W3091172233 cites W2088441464 @default.
- W3091172233 cites W2088645483 @default.
- W3091172233 cites W2098882954 @default.
- W3091172233 cites W2105115770 @default.
- W3091172233 cites W2105878007 @default.
- W3091172233 cites W2110188006 @default.
- W3091172233 cites W2112778564 @default.
- W3091172233 cites W2114286636 @default.
- W3091172233 cites W2115124692 @default.
- W3091172233 cites W2115956021 @default.
- W3091172233 cites W2117360245 @default.
- W3091172233 cites W2117637286 @default.
- W3091172233 cites W2119792393 @default.
- W3091172233 cites W2123651085 @default.
- W3091172233 cites W2124024366 @default.
- W3091172233 cites W2129656993 @default.
- W3091172233 cites W2130255071 @default.
- W3091172233 cites W2131495509 @default.
- W3091172233 cites W2131717149 @default.
- W3091172233 cites W2136022210 @default.
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- W3091172233 cites W2138524687 @default.
- W3091172233 cites W2153482276 @default.
- W3091172233 cites W2154330374 @default.
- W3091172233 cites W2157366137 @default.
- W3091172233 cites W2188422153 @default.
- W3091172233 cites W2213494633 @default.
- W3091172233 cites W2276100320 @default.
- W3091172233 cites W2343938601 @default.
- W3091172233 cites W2411387441 @default.
- W3091172233 cites W2414647500 @default.
- W3091172233 cites W2557496587 @default.
- W3091172233 cites W2612863825 @default.
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- W3091172233 cites W2783337717 @default.
- W3091172233 cites W2906339244 @default.
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- W3091172233 doi "https://doi.org/10.1002/dvdy.258" @default.
- W3091172233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33012048" @default.
- W3091172233 hasPublicationYear "2020" @default.
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