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• W3091195884 abstract "Non-alcoholic fatty liver disease (NAFLD) affects a significant number of people worldwide and currently there are no pharmacological treatments. NAFLD often presents with obesity, insulin resistance, and in some cases cardiovascular diseases. There is a clear need for treatment options to alleviate this disease since it often progresses to much more the much more severe non-alcoholic steatohepatitis (NASH). The REV-ERB nuclear receptor is a transcriptional repressor that regulates physiological processes involved in the development of NAFLD including lipogenesis and inflammation. We hypothesized that pharmacologically activating REV-ERB would suppress the progression of fatty liver in a mouse model of NASH. Using REV-ERB agonist SR9009 in a mouse NASH model, we demonstrate the beneficial effects of REV-ERB activation that led to an overall improvement of hepatic health by suppressing hepatic fibrosis and inflammatory response." @default.
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• W3091195884 date "2020-10-01" @default.
• W3091195884 modified "2023-10-01" @default.
• W3091195884 title "REV-ERB agonism improves liver pathology in a mouse model of NASH" @default.
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• W3091195884 doi "https://doi.org/10.1371/journal.pone.0236000" @default.
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