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- W3091197429 abstract "Coffee induces a health-promoting adaptive response of cells in the body. Here, we investigated enterocyte responses to AHR agonists in coffee and measured their transport across a polarized intestinal epithelium. AHR-activating potencies of Turkish, filter, and instant coffee were determined using DR CALUX® bioassay, before and after intestinal metabolization by Caco-2 cells. Furthermore, effects of coffee on induction of AHR- and Nrf2-pathway genes in Caco-2 cells were evaluated by real-time qPCR. Coffee samples showed considerable AHR-activating potencies in DR CALUX® bioassay (up to 79% of positive control activity). After incubation with Caco-2 cells, AHR activity of different coffees was between 35 and 64% of their initial value, suggesting rapid uptake and metabolization by epithelial cells. Expression of AHR-regulated gene CYP1A1 increased up to 41-fold and most Nrf2-pathway genes were up-regulated by coffee. This in vitro study may support the notion that coffee bioactives contribute to antioxidant defense and detoxification processes in vivo." @default.
- W3091197429 created "2020-10-08" @default.
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- W3091197429 date "2021-03-01" @default.
- W3091197429 modified "2023-10-15" @default.
- W3091197429 title "Coffee induces AHR- and Nrf2-mediated transcription in intestinal epithelial cells" @default.
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- W3091197429 doi "https://doi.org/10.1016/j.foodchem.2020.128261" @default.
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