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- W3091344384 endingPage "1045" @default.
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- W3091344384 abstract "Abstract The myeloarchitecture of the corpus callosum (CC) is characterized as a mosaic of distinct differences in fiber density of small- and large-diameter axons along the anterior–posterior axis; however, regional and age differences across the lifespan are not fully understood. Using multiecho T2 magnetic resonance imaging combined with multi-T2 fitting, the myelin water fraction (MWF) and geometric-mean of the intra-/extracellular water T2 (geomT2IEW) in 395 individuals (7–85 years; 41% males) were examined. The approach was validated where regional patterns along the CC closely resembled the histology; MWF matched mean axon diameter and geomT2IEW mirrored the density of large-caliber axons. Across the lifespan, MWF exhibited a quadratic association with age in all 10 CC regions with evidence of a positive linear MWF-age relationship among younger participants and minimal age differences in the remainder of the lifespan. Regarding geomT2IEW, a significant linear age × region interaction reflected positive linear age dependence mostly prominent in the regions with the highest density of small-caliber fibers—genu and splenium. In all, these two indicators characterize distinct attributes that are consistent with histology, which is a first. In addition, these results conform to rapid developmental progression of CC myelination leveling in middle age as well as age-related degradation of axon sheaths in older adults." @default.
- W3091344384 created "2020-10-08" @default.
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- W3091344384 date "2020-09-30" @default.
- W3091344384 modified "2023-10-15" @default.
- W3091344384 title "Microstructure of Human Corpus Callosum across the Lifespan: Regional Variations in Axon Caliber, Density, and Myelin Content" @default.
- W3091344384 cites W1696190749 @default.
- W3091344384 cites W1847168837 @default.
- W3091344384 cites W1955317537 @default.
- W3091344384 cites W1972308707 @default.
- W3091344384 cites W1973184578 @default.
- W3091344384 cites W1981000616 @default.
- W3091344384 cites W1981596913 @default.
- W3091344384 cites W1982643425 @default.
- W3091344384 cites W1983602360 @default.
- W3091344384 cites W1983906797 @default.
- W3091344384 cites W1984167936 @default.
- W3091344384 cites W1984232542 @default.
- W3091344384 cites W1987571170 @default.
- W3091344384 cites W1987869189 @default.
- W3091344384 cites W1990381576 @default.
- W3091344384 cites W1992805397 @default.
- W3091344384 cites W1994157465 @default.
- W3091344384 cites W1998642284 @default.
- W3091344384 cites W1999489033 @default.
- W3091344384 cites W2000974480 @default.
- W3091344384 cites W2005726513 @default.
- W3091344384 cites W2015391962 @default.
- W3091344384 cites W2024866661 @default.
- W3091344384 cites W2033283057 @default.
- W3091344384 cites W2033844003 @default.
- W3091344384 cites W2040111121 @default.
- W3091344384 cites W2044068102 @default.
- W3091344384 cites W2045137447 @default.
- W3091344384 cites W2050722132 @default.
- W3091344384 cites W2050873013 @default.
- W3091344384 cites W2059095381 @default.
- W3091344384 cites W2061426577 @default.
- W3091344384 cites W2062118197 @default.
- W3091344384 cites W2064457232 @default.
- W3091344384 cites W2069243625 @default.
- W3091344384 cites W2073333460 @default.
- W3091344384 cites W2076283593 @default.
- W3091344384 cites W2077363414 @default.
- W3091344384 cites W2079246150 @default.
- W3091344384 cites W2080737598 @default.
- W3091344384 cites W2083097918 @default.
- W3091344384 cites W2085918180 @default.
- W3091344384 cites W2093727824 @default.
- W3091344384 cites W2094016424 @default.
- W3091344384 cites W2094073779 @default.
- W3091344384 cites W2101800098 @default.
- W3091344384 cites W2103069600 @default.
- W3091344384 cites W2103374433 @default.
- W3091344384 cites W2105552075 @default.
- W3091344384 cites W2107901445 @default.
- W3091344384 cites W2111947559 @default.
- W3091344384 cites W2112778345 @default.
- W3091344384 cites W2115428913 @default.
- W3091344384 cites W2117987496 @default.
- W3091344384 cites W2119980272 @default.
- W3091344384 cites W2126587429 @default.
- W3091344384 cites W2136573752 @default.
- W3091344384 cites W2143316684 @default.
- W3091344384 cites W2146523233 @default.
- W3091344384 cites W2147597108 @default.
- W3091344384 cites W2152046999 @default.
- W3091344384 cites W2154288487 @default.
- W3091344384 cites W2157481067 @default.
- W3091344384 cites W2166312597 @default.
- W3091344384 cites W2169459006 @default.
- W3091344384 cites W2334526765 @default.
- W3091344384 cites W2504350669 @default.
- W3091344384 cites W2511297583 @default.
- W3091344384 cites W2563669845 @default.
- W3091344384 cites W2563734768 @default.
- W3091344384 cites W2590185774 @default.
- W3091344384 cites W2601282981 @default.
- W3091344384 cites W2611060850 @default.
- W3091344384 cites W2755398378 @default.
- W3091344384 cites W2782273750 @default.
- W3091344384 cites W2915523305 @default.
- W3091344384 cites W2931590677 @default.
- W3091344384 cites W2977883299 @default.
- W3091344384 cites W2988482730 @default.
- W3091344384 cites W3007450150 @default.
- W3091344384 cites W3012614496 @default.
- W3091344384 cites W4255894213 @default.
- W3091344384 doi "https://doi.org/10.1093/cercor/bhaa272" @default.
- W3091344384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7906774" @default.
- W3091344384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32995843" @default.