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- W3091389077 abstract "Well-timed interaction of correctly functioning maternal immune cells is essential to facilitate healthy placenta formation, because the uterine immune environment has to tolerate the semi-allogeneic fetus and allow adequate trophoblast invasion. Here, we assess the uterine immune signature before and during pregnancy. Extensive supervised and unsupervised flow cytometry clustering strategies not only show a general increase in immune memory throughout pregnancy but also reveal the continuous presence of B cells. Contrary to the belief that B cells are merely a consequence of uterine pathology, decidual B cells produce IL-10 and are found to be localized in clusters, together with Foxp3pos T cells. Our findings therefore suggest a role for B cells in healthy pregnancy." @default.
- W3091389077 created "2020-10-08" @default.
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- W3091389077 date "2020-09-01" @default.
- W3091389077 modified "2023-10-01" @default.
- W3091389077 title "Clusters of Tolerogenic B Cells Feature in the Dynamic Immunological Landscape of the Pregnant Uterus" @default.
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- W3091389077 doi "https://doi.org/10.1016/j.celrep.2020.108204" @default.
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