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- W3091494080 abstract "Prophylactic vaccines remain the best approach for controlling the human immunodeficiency virus-1 (HIV-1) transmission. Despite the limited efficacy of the RV144 trial in Thailand, there is still no vaccine candidate that has been proven successful. Consequently, great efforts have been made to improve HIV-1 antigens design and discover delivery platforms for optimal immune elicitation. Owing to immunogenic, structural and functional diversity, virus-like particles (VLPs) could act as efficient vaccine carriers to display HIV-1 immunogens and provide a variety of HIV-1 vaccine development strategies as well as prime-boost regimes. Here, we describe VLP-based HIV-1 vaccine candidates that have been enrolled in HIV-1 clinical trials and summarize current advances and challenges according to preclinical results obtained from five distinct strategies. This mini-review provides multiple perspectives to help in developing new generations of VLP-based HIV-1 vaccine candidates with better capacity to elicit specific anti-HIV immune responses." @default.
- W3091494080 created "2020-10-08" @default.
- W3091494080 creator A5033668383 @default.
- W3091494080 creator A5063894604 @default.
- W3091494080 creator A5067174207 @default.
- W3091494080 date "2020-09-30" @default.
- W3091494080 modified "2023-10-18" @default.
- W3091494080 title "Design Concepts of Virus-Like Particle-Based HIV-1 Vaccines" @default.
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- W3091494080 doi "https://doi.org/10.3389/fimmu.2020.573157" @default.
- W3091494080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7561392" @default.
- W3091494080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33117367" @default.
- W3091494080 hasPublicationYear "2020" @default.
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