Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091498413> ?p ?o ?g. }
- W3091498413 endingPage "25454" @default.
- W3091498413 startingPage "25445" @default.
- W3091498413 abstract "Significance Allostery is a fundamental mechanism by which proteins recognize environmental cues and elicit a response at a distal site. Allosteric signaling is essential in the regulation of myriad cellular processes, yet its molecular basis is poorly understood. Compared to traditional approaches that rely on structure to understand allostery, we chose a high-throughput function-centric approach. Using systematic mutagenesis, we found allosteric signaling to be highly adaptable where a mutation that inactivates allostery can be functionally compensated by another distal mutation. Although functionally important, allosteric hotspots, residues critical for signaling, were poorly conserved. In contrast, residues important for structural stability are significantly conserved, suggesting evolution selects fold over function. Our approach can lead to broad molecular principles of allostery." @default.
- W3091498413 created "2020-10-08" @default.
- W3091498413 creator A5004430693 @default.
- W3091498413 creator A5036789652 @default.
- W3091498413 creator A5056495875 @default.
- W3091498413 creator A5061028014 @default.
- W3091498413 creator A5080687348 @default.
- W3091498413 date "2020-09-30" @default.
- W3091498413 modified "2023-10-01" @default.
- W3091498413 title "Functional plasticity and evolutionary adaptation of allosteric regulation" @default.
- W3091498413 cites W1816644759 @default.
- W3091498413 cites W1939988704 @default.
- W3091498413 cites W1964439982 @default.
- W3091498413 cites W1967095911 @default.
- W3091498413 cites W1971725855 @default.
- W3091498413 cites W1982874561 @default.
- W3091498413 cites W2000023323 @default.
- W3091498413 cites W2009123297 @default.
- W3091498413 cites W2014252415 @default.
- W3091498413 cites W2015115438 @default.
- W3091498413 cites W2015807753 @default.
- W3091498413 cites W2017757921 @default.
- W3091498413 cites W2018645639 @default.
- W3091498413 cites W2027309027 @default.
- W3091498413 cites W2049524895 @default.
- W3091498413 cites W2049682677 @default.
- W3091498413 cites W2052018677 @default.
- W3091498413 cites W2060588922 @default.
- W3091498413 cites W2065652080 @default.
- W3091498413 cites W2074129172 @default.
- W3091498413 cites W2090143109 @default.
- W3091498413 cites W2091060891 @default.
- W3091498413 cites W2093607662 @default.
- W3091498413 cites W2101893648 @default.
- W3091498413 cites W2102964870 @default.
- W3091498413 cites W2110403565 @default.
- W3091498413 cites W2115152262 @default.
- W3091498413 cites W2120772351 @default.
- W3091498413 cites W2122854841 @default.
- W3091498413 cites W2127322768 @default.
- W3091498413 cites W2134742468 @default.
- W3091498413 cites W2146223593 @default.
- W3091498413 cites W2153457180 @default.
- W3091498413 cites W2153953580 @default.
- W3091498413 cites W2157107905 @default.
- W3091498413 cites W2159237107 @default.
- W3091498413 cites W2159291387 @default.
- W3091498413 cites W2162667876 @default.
- W3091498413 cites W2169515696 @default.
- W3091498413 cites W2283716387 @default.
- W3091498413 cites W2283818235 @default.
- W3091498413 cites W2331941237 @default.
- W3091498413 cites W2423210081 @default.
- W3091498413 cites W2573853086 @default.
- W3091498413 cites W2891358505 @default.
- W3091498413 cites W2898806520 @default.
- W3091498413 cites W2911398658 @default.
- W3091498413 cites W2918063357 @default.
- W3091498413 cites W2971141280 @default.
- W3091498413 cites W2974168307 @default.
- W3091498413 cites W3007543395 @default.
- W3091498413 doi "https://doi.org/10.1073/pnas.2002613117" @default.
- W3091498413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7568325" @default.
- W3091498413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32999067" @default.
- W3091498413 hasPublicationYear "2020" @default.
- W3091498413 type Work @default.
- W3091498413 sameAs 3091498413 @default.
- W3091498413 citedByCount "53" @default.
- W3091498413 countsByYear W30914984132020 @default.
- W3091498413 countsByYear W30914984132021 @default.
- W3091498413 countsByYear W30914984132022 @default.
- W3091498413 countsByYear W30914984132023 @default.
- W3091498413 crossrefType "journal-article" @default.
- W3091498413 hasAuthorship W3091498413A5004430693 @default.
- W3091498413 hasAuthorship W3091498413A5036789652 @default.
- W3091498413 hasAuthorship W3091498413A5056495875 @default.
- W3091498413 hasAuthorship W3091498413A5061028014 @default.
- W3091498413 hasAuthorship W3091498413A5080687348 @default.
- W3091498413 hasBestOaLocation W30914984131 @default.
- W3091498413 hasConcept C104317684 @default.
- W3091498413 hasConcept C109964505 @default.
- W3091498413 hasConcept C139807058 @default.
- W3091498413 hasConcept C14036430 @default.
- W3091498413 hasConcept C16318435 @default.
- W3091498413 hasConcept C166342909 @default.
- W3091498413 hasConcept C169760540 @default.
- W3091498413 hasConcept C170493617 @default.
- W3091498413 hasConcept C501734568 @default.
- W3091498413 hasConcept C54355233 @default.
- W3091498413 hasConcept C70721500 @default.
- W3091498413 hasConcept C86803240 @default.
- W3091498413 hasConcept C95444343 @default.
- W3091498413 hasConceptScore W3091498413C104317684 @default.
- W3091498413 hasConceptScore W3091498413C109964505 @default.
- W3091498413 hasConceptScore W3091498413C139807058 @default.
- W3091498413 hasConceptScore W3091498413C14036430 @default.
- W3091498413 hasConceptScore W3091498413C16318435 @default.
- W3091498413 hasConceptScore W3091498413C166342909 @default.