Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091500898> ?p ?o ?g. }
- W3091500898 abstract "Abstract A novel IDA- La NDT derivative was able to reach the highest productivity in the biosynthesis of a well-known antitumoral agent called decitabine. However, the combination of two simple and inexpensive techniques such as ionic absorption and gel entrapment with the incorporation of a bionanocomposite such as bentonite significantly improved the stability of this biocatalyst. These modifications allowed the enhancement of storage stability (for at least 18 months), reusability (400 h of successive batches without significant loss of its initial activity), and thermal and solvent stability with respect to the non-entrapped derivative. Moreover, reaction conditions were optimized by increasing the solubility of 5-aza by dilution with dimethylsulfoxide. Therefore, a scale-up of the bioprocess was assayed using the developed biocatalyst, obtaining 221 mg/L·h of DAC. Finally, green parameters were calculated using the nanostabilized biocatalyst, whose results indicated that it was able to biosynthesize DAC by a smooth, cheap, and environmentally friendly methodology." @default.
- W3091500898 created "2020-10-08" @default.
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- W3091500898 date "2020-09-29" @default.
- W3091500898 modified "2023-10-16" @default.
- W3091500898 title "Decitabine bioproduction using a biocatalyst with improved stability by adding nanocomposites" @default.
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- W3091500898 doi "https://doi.org/10.1186/s13568-020-01109-0" @default.
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