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- W3091510050 abstract "The World Health Organization has reported around 50 million people worldwide suffer from epilepsy. Epilepsy is a neurological disorder caused by abnormal brain activity that leads to spontaneous seizures. The complications that arise with epilepsy can heavily limit the quality of life for those affected and can lead to death. The seizures that occur are due to an imbalance of hyper excitatory neuronal activity and a lack of inhibitory neuronal response. There have been beneficial advancements in cell therapies that have great promise in treating epilepsy compared to previous therapeutics. Using GABAergic precursors derived from human embryonic stem cells (hESCs) made in vitro, we performed a pilot study transplanting these cells into the hippocampus of postnatal 2-day old mice. After determining pup hippocampal coordinates, differentiating the GABAergic precursor neurons, and transplanting the cells in the hippocampus of the neonatal mice, we saw cell survival 2-months after transplantation. This pilot study is crucial for future development of cell transplantations that target the hippocampus of neonatal mice. (Less)" @default.
- W3091510050 created "2020-10-08" @default.
- W3091510050 creator A5029504688 @default.
- W3091510050 date "2020-01-01" @default.
- W3091510050 modified "2023-09-27" @default.
- W3091510050 title "Transplantation of GABAergic precursor neurons generated from hESCs in postnatal day 2 mice" @default.
- W3091510050 hasPublicationYear "2020" @default.
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