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- W3091531057 endingPage "2518" @default.
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- W3091531057 abstract "Abstract Recent studies have shown that G protein‐coupled receptors (GPCRs), the largest signal‐conveying receptor family, are targets for mutations occurring frequently in different cancer types. GPCR alterations associated with cancer development represent significant challenges for the discovery and the advancement of targeted therapeutics. Among the different molecules that can activate GPCRs, we focused on two molecules that exert their biological actions regulating many typical features of tumorigenesis such as cellular proliferation, survival, and invasion: somatostatin and melatonin. The modulation of signaling pathways, that involves these two molecules, opens an interesting scenario for cancer therapy, with the opportunity to act at different molecular levels. Therefore, the aim of this review is the analysis of the biological activity and the therapeutic potential of somatostatin and melatonin, displaying a high affinity for GPCRs, that interfere with cancer development and maintenance." @default.
- W3091531057 created "2020-10-08" @default.
- W3091531057 creator A5043104677 @default.
- W3091531057 creator A5050528102 @default.
- W3091531057 creator A5055049429 @default.
- W3091531057 creator A5058341587 @default.
- W3091531057 creator A5074326702 @default.
- W3091531057 creator A5082203114 @default.
- W3091531057 creator A5087091137 @default.
- W3091531057 date "2020-09-28" @default.
- W3091531057 modified "2023-10-14" @default.
- W3091531057 title "Two neuroendocrine G protein‐coupled receptor molecules, somatostatin and melatonin: Physiology of signal transduction and therapeutic perspectives" @default.
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