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- W3091552899 abstract "Abstract We examined the activation and effector functions of lung macrophages in mediating immunity against helminth parasites. Using fate mapping mice, we showed that monocytes recruited to the lung assume an alveolar macrophage phenotype and comprise as many as 10% of alveolar macrophages by 7 days after inoculation. Monocyte-derived alveolar macrophages assume distinct transcriptional and metabolic profiles that include high levels of arginase expression and preferentially mediate helminth damage, both of which are dependent on neutrophil help. In further studies, arginase was shown to mediate helminth killing through localized depletion of arginine." @default.
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- W3091552899 date "2020-10-02" @default.
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- W3091552899 title "Monocyte-derived alveolar macrophages mediate resistance to migrating helminths through depletion of arginine availability" @default.
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