FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091639936> ?p ?o ?g. }

• W3091639936 abstract "In some settings, cancer cells responding to treatment undergo an immunogenic form of cell death that is associated with the abundant emission of danger signals in the form of damage-associated molecular patterns. Accumulating preclinical and clinical evidence indicates that danger signals play a crucial role in the (re-)activation of antitumor immune responses in vivo, thus having a major impact on patient prognosis. We have previously demonstrated that the presence of calreticulin on the surface of malignant blasts is a positive prognostic biomarker for patients with acute myeloid leukemia (AML). Calreticulin exposure not only correlated with enhanced T-cell-dependent antitumor immunity in this setting but also affected the number of circulating natural killer (NK) cells upon restoration of normal hematopoiesis. Here, we report that calreticulin exposure on malignant blasts is associated with enhanced NK cell cytotoxic and secretory functions, both in AML patients and in vivo in mice. The ability of calreticulin to stimulate NK-cells relies on CD11c+CD14high cells that, upon exposure to CRT, express higher levels of IL-15Rα, maturation markers (CD86 and HLA- DR) and CCR7. CRT exposure on malignant blasts also correlates with the upregulation of genes coding for type I interferon. This suggests that CD11c+CD14high cells have increased capacity to migrate to secondary lymphoid organs, where can efficiently deliver stimulatory signals (IL-15Rα/IL- 15) to NK cells. These findings delineate a multipronged, clinically relevant mechanism whereby surface-exposed calreticulin favors NK-cell activation in AML patients. Disclosure Information I. Truxova: None. L. Kasikova: None. C. Salek: None. M. Hensler: None. D. Lysak: None. P. Holicek: None. P. Bilkova: None. M. Holubova: None. X. Chen: None. R. Mikyskova: None. M. Reinis: None. M. Kovar: None. B. Tomalova: None. J.P. Kline: None. L. Galluzzi: None. R. Spisek: None. J. Fucikova: None." @default.
• W3091639936 created "2020-10-08" @default.
• W3091639936 creator A5004954459 @default.
• W3091639936 creator A5010063233 @default.
• W3091639936 creator A5011373942 @default.
• W3091639936 creator A5013446879 @default.
• W3091639936 creator A5017733356 @default.
• W3091639936 creator A5018688358 @default.
• W3091639936 creator A5023684480 @default.
• W3091639936 creator A5026488935 @default.
• W3091639936 creator A5034403436 @default.
• W3091639936 creator A5039345319 @default.
• W3091639936 creator A5047558087 @default.
• W3091639936 creator A5049805426 @default.
• W3091639936 creator A5060179690 @default.
• W3091639936 creator A5068758499 @default.
• W3091639936 creator A5071827163 @default.
• W3091639936 creator A5079771787 @default.
• W3091639936 creator A5090378329 @default.
• W3091639936 date "2020-10-01" @default.
• W3091639936 modified "2023-10-17" @default.
• W3091639936 title "P03.24 Calreticulin exposure on malignant blasts correlates with improved NK cell-mediated cytotoxicity in AML patients" @default.
• W3091639936 doi "https://doi.org/10.1136/jitc-2020-itoc7.62" @default.
• W3091639936 hasPublicationYear "2020" @default.
• W3091639936 type Work @default.
• W3091639936 sameAs 3091639936 @default.
• W3091639936 citedByCount "0" @default.
• W3091639936 crossrefType "journal-article" @default.
• W3091639936 hasAuthorship W3091639936A5004954459 @default.
• W3091639936 hasAuthorship W3091639936A5010063233 @default.
• W3091639936 hasAuthorship W3091639936A5011373942 @default.
• W3091639936 hasAuthorship W3091639936A5013446879 @default.
• W3091639936 hasAuthorship W3091639936A5017733356 @default.
• W3091639936 hasAuthorship W3091639936A5018688358 @default.
• W3091639936 hasAuthorship W3091639936A5023684480 @default.
• W3091639936 hasAuthorship W3091639936A5026488935 @default.
• W3091639936 hasAuthorship W3091639936A5034403436 @default.
• W3091639936 hasAuthorship W3091639936A5039345319 @default.
• W3091639936 hasAuthorship W3091639936A5047558087 @default.
• W3091639936 hasAuthorship W3091639936A5049805426 @default.
• W3091639936 hasAuthorship W3091639936A5060179690 @default.
• W3091639936 hasAuthorship W3091639936A5068758499 @default.
• W3091639936 hasAuthorship W3091639936A5071827163 @default.
• W3091639936 hasAuthorship W3091639936A5079771787 @default.
• W3091639936 hasAuthorship W3091639936A5090378329 @default.
• W3091639936 hasBestOaLocation W30916399361 @default.
• W3091639936 hasConcept C104317684 @default.
• W3091639936 hasConcept C127716648 @default.
• W3091639936 hasConcept C154317977 @default.
• W3091639936 hasConcept C158617107 @default.
• W3091639936 hasConcept C167672396 @default.
• W3091639936 hasConcept C183193105 @default.
• W3091639936 hasConcept C202751555 @default.
• W3091639936 hasConcept C203014093 @default.
• W3091639936 hasConcept C2776062744 @default.
• W3091639936 hasConcept C2776090121 @default.
• W3091639936 hasConcept C2777701055 @default.
• W3091639936 hasConcept C2777877232 @default.
• W3091639936 hasConcept C2778729363 @default.
• W3091639936 hasConcept C2779919695 @default.
• W3091639936 hasConcept C2781101188 @default.
• W3091639936 hasConcept C47450691 @default.
• W3091639936 hasConcept C502942594 @default.
• W3091639936 hasConcept C55493867 @default.
• W3091639936 hasConcept C71924100 @default.
• W3091639936 hasConcept C86803240 @default.
• W3091639936 hasConcept C8891405 @default.
• W3091639936 hasConcept C95444343 @default.
• W3091639936 hasConceptScore W3091639936C104317684 @default.
• W3091639936 hasConceptScore W3091639936C127716648 @default.
• W3091639936 hasConceptScore W3091639936C154317977 @default.
• W3091639936 hasConceptScore W3091639936C158617107 @default.
• W3091639936 hasConceptScore W3091639936C167672396 @default.
• W3091639936 hasConceptScore W3091639936C183193105 @default.
• W3091639936 hasConceptScore W3091639936C202751555 @default.
• W3091639936 hasConceptScore W3091639936C203014093 @default.
• W3091639936 hasConceptScore W3091639936C2776062744 @default.
• W3091639936 hasConceptScore W3091639936C2776090121 @default.
• W3091639936 hasConceptScore W3091639936C2777701055 @default.
• W3091639936 hasConceptScore W3091639936C2777877232 @default.
• W3091639936 hasConceptScore W3091639936C2778729363 @default.
• W3091639936 hasConceptScore W3091639936C2779919695 @default.
• W3091639936 hasConceptScore W3091639936C2781101188 @default.
• W3091639936 hasConceptScore W3091639936C47450691 @default.
• W3091639936 hasConceptScore W3091639936C502942594 @default.
• W3091639936 hasConceptScore W3091639936C55493867 @default.
• W3091639936 hasConceptScore W3091639936C71924100 @default.
• W3091639936 hasConceptScore W3091639936C86803240 @default.
• W3091639936 hasConceptScore W3091639936C8891405 @default.
• W3091639936 hasConceptScore W3091639936C95444343 @default.
• W3091639936 hasLocation W30916399361 @default.
• W3091639936 hasOpenAccess W3091639936 @default.
• W3091639936 hasPrimaryLocation W30916399361 @default.
• W3091639936 hasRelatedWork W10348948 @default.
• W3091639936 hasRelatedWork W1283782 @default.
• W3091639936 hasRelatedWork W14283030 @default.
• W3091639936 hasRelatedWork W14691331 @default.
• W3091639936 hasRelatedWork W2495403 @default.
• W3091639936 hasRelatedWork W2522140 @default.
• W3091639936 hasRelatedWork W4041773 @default.

• next