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- W3091769503 abstract "Reaction monitoring is crucial in order to guide pharmaceutical chemical processes towards successful outcomes. Many drug substances require the application of water/additive-free solvents to guide process efforts which are intrinsically incompatible with reversed phase liquid chromatography (RPLC) conditions. Sub/supercritical fluid chromatography (SFC) helps to overcome many of these challenges delivering unmatched speed, with low cost, high-efficiency and an additive-free environment ideal for reaction monitoring of species chemically susceptible to water. Herein, we provide several examples where traditional RPLC fails or delivers sub-optimal performance in monitoring processes. These examples include using additive-free SFC-UV and SFC-MS methodologies to overcome difficulties associated with: 1) on-column RPLC hydrolysis, 2) improving normal phase liquid chromatography, replacing capillary zone electrophoresis methods, and 3) avoiding the use of tedious pre-column derivatization procedures." @default.
- W3091769503 created "2020-10-15" @default.
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- W3091769503 date "2021-02-01" @default.
- W3091769503 modified "2023-09-26" @default.
- W3091769503 title "Advanced reaction monitoring of pharmaceutical processes enabled with sub/supercritical fluid chromatography" @default.
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- W3091769503 doi "https://doi.org/10.1016/j.supflu.2020.105068" @default.
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