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• W3091781593 abstract "Background: To verify the surgical and oncological outcome of ALPPS performed for intrahepatic cholangiocarcinoma (ICC) patients. Methods: This cohort study consisted of 1) safety and efficacy analysis of patients undergoing ALPPS for local advanced ICC at 31 international centers, mainly from the ALPPS registry, 2) survival analysis with propensity score (PS) matched patients with non-metastatic ICC receiving palliative chemotherapy (CTx) from the SEER database. Results: 102 patients undergoing ALPPS were recruited. 99 patients have completed the second stage, with median FLR/ BW (body weight) of 0.84% and median inter-stage duration of 11 days. Trisetionectomy was performed in 78.7%. Morbidity after hepatectomy was 42.4%, with severe complications(Clavien-Dindo grade 3b and more)in 35.4%. The 90-day mortality after ALPPS was 20.8%. Multivariate analysis revealed 'FLR/BW ratio <0.84' to be the only risk factor for severe complications. R0 resection was reported in 87.4%. The 3-year recurrence rate was 91.7%, with median recurrence time of 8.4 months. The median overall survival was 26.4 months.After PS matching by age, gender, tumor stage and lymph node status, 88 patients in each group (ALPPS vs CTx) were identified. The 90-day mortality in ALPPS group was higher than CTx group (21.6% vs 12.5%). Despite that, a superior overall survival was found in ALPPS group with the median overall survival of 26.4 months (14 months in CTx group), 1, 2, 3-year survival rate 82.4%, 70.5% and 39.6% respectively (51.2%, 21.4% and 11.3% in CTx group respectively, p < 0.004). (Fig.1) Conclusion: ALPPS has high efficacy to achieve R0 resection in local advanced ICC. A significant survival benefit of ALPPS is found over matched group of chemotherapy. To reduce the considerable severe morbidity and 90-day mortality, caution should be taken in patients with insufficient FLR." @default.
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• W3091781593 date "2020-01-01" @default.
• W3091781593 modified "2023-10-09" @default.
• W3091781593 title "Safety and efficacy of ALPPS for intrahepatic cholangiocarcinoma in 102 patients: A multi-center study" @default.
• W3091781593 doi "https://doi.org/10.1016/j.hpb.2020.04.403" @default.
• W3091781593 hasPublicationYear "2020" @default.
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