FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091814408> ?p ?o ?g. }

• W3091814408 endingPage "118886" @default.
• W3091814408 startingPage "118886" @default.
• W3091814408 abstract "Platelets have been extensively implicated in the progression of cancer and platelet-derived extracellular vesicles (PEVs) are gaining growing attention as potential mediators of the platelet-cancer interplay. PEVs are shed from platelet membrane in response to extracellular stimuli and carry important biological signals for intercellular communication. In this study we demonstrate that PEVs specifically bind to different breast cancer cells and elicit cell-specific functional responses. PEVs were massively internalized by the metastatic cell lines MDA-MB-231 and SKBR3 and the ductal carcinoma cell line BT474, but not by the MCF-7 cell line. In SKBR3 cells, PEVs decreased mitochondrial dehydrogenase activities and altered cell cycle progression without affecting cell viability. Conversely, PEVs potently stimulated migration and invasion of MDA-MB-231, without affecting the distribution in the different phases of the cell cycle. In all the analyzed breast cancer cells, PEVs triggered a sustained increase of intracellular Ca2+, but only in MDA-MB-231 cells, this was associated to the stimulation of selected signaling proteins implicated in migration, including p38MAPK and myosin light chain. Importantly, inhibition of myosin light chain phosphorylation by a Rho kinase inhibitor prevented PEVs-stimulated migration of MDA-MB-231 cells. Our results demonstrate that PEVs are versatile regulators of cancer cell behavior and elicit a variety of different responses depending on the specific breast cancer cell subtype." @default.
• W3091814408 created "2020-10-15" @default.
• W3091814408 creator A5021866478 @default.
• W3091814408 creator A5026120374 @default.
• W3091814408 creator A5054070979 @default.
• W3091814408 creator A5059628582 @default.
• W3091814408 creator A5066721156 @default.
• W3091814408 creator A5068461233 @default.
• W3091814408 creator A5085078657 @default.
• W3091814408 creator A5086552669 @default.
• W3091814408 creator A5091129502 @default.
• W3091814408 date "2021-01-01" @default.
• W3091814408 modified "2023-10-03" @default.
• W3091814408 title "Platelet-derived extracellular vesicles regulate cell cycle progression and cell migration in breast cancer cells" @default.
• W3091814408 cites W1423501786 @default.
• W3091814408 cites W1599277155 @default.
• W3091814408 cites W1842417765 @default.
• W3091814408 cites W1900545099 @default.
• W3091814408 cites W1935876833 @default.
• W3091814408 cites W1968519475 @default.
• W3091814408 cites W1978654172 @default.
• W3091814408 cites W1991462747 @default.
• W3091814408 cites W1994930469 @default.
• W3091814408 cites W1998599956 @default.
• W3091814408 cites W2011575213 @default.
• W3091814408 cites W2016656365 @default.
• W3091814408 cites W2020417605 @default.
• W3091814408 cites W2028092741 @default.
• W3091814408 cites W2031882640 @default.
• W3091814408 cites W2036208464 @default.
• W3091814408 cites W2074892413 @default.
• W3091814408 cites W2088001386 @default.
• W3091814408 cites W2124339684 @default.
• W3091814408 cites W2142739240 @default.
• W3091814408 cites W2146326454 @default.
• W3091814408 cites W2147582887 @default.
• W3091814408 cites W2162073651 @default.
• W3091814408 cites W2196123883 @default.
• W3091814408 cites W2218307669 @default.
• W3091814408 cites W2235908771 @default.
• W3091814408 cites W2395612161 @default.
• W3091814408 cites W2476697612 @default.
• W3091814408 cites W2513477456 @default.
• W3091814408 cites W2560656631 @default.
• W3091814408 cites W2566299136 @default.
• W3091814408 cites W2570400167 @default.
• W3091814408 cites W2586407709 @default.
• W3091814408 cites W2604154469 @default.
• W3091814408 cites W2613750599 @default.
• W3091814408 cites W2748348423 @default.
• W3091814408 cites W2749725594 @default.
• W3091814408 cites W2759033938 @default.
• W3091814408 cites W2772596757 @default.
• W3091814408 cites W2789502632 @default.
• W3091814408 cites W2799964844 @default.
• W3091814408 cites W2889611453 @default.
• W3091814408 cites W2897062681 @default.
• W3091814408 cites W2900914993 @default.
• W3091814408 cites W2924762180 @default.
• W3091814408 cites W2939351210 @default.
• W3091814408 cites W2949351365 @default.
• W3091814408 cites W2981398717 @default.
• W3091814408 cites W2987607116 @default.
• W3091814408 cites W32984090 @default.
• W3091814408 cites W4211032970 @default.
• W3091814408 doi "https://doi.org/10.1016/j.bbamcr.2020.118886" @default.
• W3091814408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33039555" @default.
• W3091814408 hasPublicationYear "2021" @default.
• W3091814408 type Work @default.
• W3091814408 sameAs 3091814408 @default.
• W3091814408 citedByCount "16" @default.
• W3091814408 countsByYear W30918144082021 @default.
• W3091814408 countsByYear W30918144082022 @default.
• W3091814408 countsByYear W30918144082023 @default.
• W3091814408 crossrefType "journal-article" @default.
• W3091814408 hasAuthorship W3091814408A5021866478 @default.
• W3091814408 hasAuthorship W3091814408A5026120374 @default.
• W3091814408 hasAuthorship W3091814408A5054070979 @default.
• W3091814408 hasAuthorship W3091814408A5059628582 @default.
• W3091814408 hasAuthorship W3091814408A5066721156 @default.
• W3091814408 hasAuthorship W3091814408A5068461233 @default.
• W3091814408 hasAuthorship W3091814408A5085078657 @default.
• W3091814408 hasAuthorship W3091814408A5086552669 @default.
• W3091814408 hasAuthorship W3091814408A5091129502 @default.
• W3091814408 hasConcept C121608353 @default.
• W3091814408 hasConcept C137738243 @default.
• W3091814408 hasConcept C1491633281 @default.
• W3091814408 hasConcept C191560914 @default.
• W3091814408 hasConcept C29537977 @default.
• W3091814408 hasConcept C2994423619 @default.
• W3091814408 hasConcept C502942594 @default.
• W3091814408 hasConcept C54355233 @default.
• W3091814408 hasConcept C55493867 @default.
• W3091814408 hasConcept C6997183 @default.
• W3091814408 hasConcept C79879829 @default.
• W3091814408 hasConcept C8035138 @default.
• W3091814408 hasConcept C86803240 @default.
• W3091814408 hasConcept C95444343 @default.

• next