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• W3091842446 abstract "Significance Large cranial reconstructions are increasingly performed worldwide and still represent a substantial clinical challenge. The gold standard, autologous bone, has limited availability and high donor-site morbidity. Current alloplastic materials are associated with high complication and failure rates. This study shows the capacity of a customized, purely synthetic, 3D-manufactured bioceramic implant to regenerate and restore large cranial defects with mature, well-vascularized bone, with a morphology, ultrastructure, and composition similar to those of native skull bone. This approach triggers the regenerative potential of host tissue by tailoring the implant composition and design. The regeneration of large defects using purely synthetic material without adjunct cell therapy or growth factors represents a major advancement for rehabilitating patients in need of large cranial reconstructions." @default.
• W3091842446 created "2020-10-15" @default.
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• W3091842446 date "2020-10-12" @default.
• W3091842446 modified "2023-10-11" @default.
• W3091842446 title "In situ bone regeneration of large cranial defects using synthetic ceramic implants with a tailored composition and design" @default.
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• W3091842446 doi "https://doi.org/10.1073/pnas.2007635117" @default.
• W3091842446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7604495" @default.
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