FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091849290> ?p ?o ?g. }

• W3091849290 endingPage "13" @default.
• W3091849290 startingPage "1" @default.
• W3091849290 abstract "Chronic renal artery stenosis is considered one of the most common causes of renovascular hypertension (RH). Chronic hypoxia can lead to irreversible damage to renal tissue and to a progressive deterioration of renal function. We have previously shown that bone marrow-derived mesenchymal stem cells (BMSCs) improved renal parenchyma and function in a model of RH (2 kidneys, 1 clip model (2K-1C) in rats. Microvesicles (MVs) and exosomes (EXs) released by MSCs have been shown to induce effects similar to those induced by whole cells but with fewer side effects. In this study, we compared the effects of adipose-derived MSCs (ASCs) with those of the MVs and EXs released by ASCs on tissue inflammation and renal function in 2 K-1C rats.Flow cytometry analysis showed that even after 15 days, ASCs were still detected in both kidneys. The expression of a stem cell homing marker (SDF1-α) was increased in ASC-treated animals in both the stenotic and contralateral kidneys. Interestingly, SDF1-α expression was also increased in MV- and EX-treated animals. A hypoxia marker (HIF1-α) was upregulated in the stenotic kidney, and treatments with ASCs, MVs, and EXs were effective in reducing the expression of this marker. Stenotic animals showed a progressive increase in systolic blood pressure (SBP), while animals treated with ASCs, MVs, and EXs showed a stabilization of SBP, and this stabilization was similar among the different treatments. Stenotic animals developed significant proteinuria, which was reduced by ASCs and MVs but not by EXs. The increased expression of Col I and TGFβ in both kidneys was reduced by all the treatments, and these treatments also effectively increased the expression of the anti-inflammatory cytokine IL-10 in both kidneys; however, only ASCs were able to reduce the overexpression of the proinflammatory cytokine IL-1β in both kidneys of 2K-1C animals.The results of this study demonstrated that the EVs released by ASCs produced beneficial results but with lower efficacy than whole cells. ASCs produced stronger effects in this model of renal chronic hypoxia, and the use of EVs instead of whole cells should be evaluated depending on the parameter to be corrected." @default.
• W3091849290 created "2020-10-15" @default.
• W3091849290 creator A5015348925 @default.
• W3091849290 creator A5019837543 @default.
• W3091849290 creator A5038672698 @default.
• W3091849290 creator A5045665341 @default.
• W3091849290 creator A5064265738 @default.
• W3091849290 creator A5090411849 @default.
• W3091849290 date "2020-10-08" @default.
• W3091849290 modified "2023-10-15" @default.
• W3091849290 title "Comparison of the Effects of Mesenchymal Stem Cells with Their Extracellular Vesicles on the Treatment of Kidney Damage Induced by Chronic Renal Artery Stenosis" @default.
• W3091849290 cites W1494355500 @default.
• W3091849290 cites W1560486856 @default.
• W3091849290 cites W1967432664 @default.
• W3091849290 cites W1968553391 @default.
• W3091849290 cites W1982861439 @default.
• W3091849290 cites W1984974003 @default.
• W3091849290 cites W1986321004 @default.
• W3091849290 cites W1990950572 @default.
• W3091849290 cites W1993088005 @default.
• W3091849290 cites W1994069577 @default.
• W3091849290 cites W2000630485 @default.
• W3091849290 cites W2003343932 @default.
• W3091849290 cites W2012829789 @default.
• W3091849290 cites W2014882299 @default.
• W3091849290 cites W2027661234 @default.
• W3091849290 cites W2043263890 @default.
• W3091849290 cites W2044657247 @default.
• W3091849290 cites W2047288034 @default.
• W3091849290 cites W2055313665 @default.
• W3091849290 cites W2071816357 @default.
• W3091849290 cites W2107284173 @default.
• W3091849290 cites W2113201985 @default.
• W3091849290 cites W2114741924 @default.
• W3091849290 cites W2115363040 @default.
• W3091849290 cites W2135378032 @default.
• W3091849290 cites W2138094870 @default.
• W3091849290 cites W2140909944 @default.
• W3091849290 cites W2148367988 @default.
• W3091849290 cites W2151584545 @default.
• W3091849290 cites W2154215235 @default.
• W3091849290 cites W2159401023 @default.
• W3091849290 cites W2163087495 @default.
• W3091849290 cites W2207291742 @default.
• W3091849290 cites W2290646886 @default.
• W3091849290 cites W2306889839 @default.
• W3091849290 cites W2424306059 @default.
• W3091849290 cites W2487947432 @default.
• W3091849290 cites W2516370793 @default.
• W3091849290 cites W2518133141 @default.
• W3091849290 cites W2522253079 @default.
• W3091849290 cites W2542999988 @default.
• W3091849290 cites W2563463363 @default.
• W3091849290 cites W2611151408 @default.
• W3091849290 cites W2986135186 @default.
• W3091849290 doi "https://doi.org/10.1155/2020/8814574" @default.
• W3091849290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7568167" @default.
• W3091849290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33101418" @default.
• W3091849290 hasPublicationYear "2020" @default.
• W3091849290 type Work @default.
• W3091849290 sameAs 3091849290 @default.
• W3091849290 citedByCount "11" @default.
• W3091849290 countsByYear W30918492902021 @default.
• W3091849290 countsByYear W30918492902022 @default.
• W3091849290 countsByYear W30918492902023 @default.
• W3091849290 crossrefType "journal-article" @default.
• W3091849290 hasAuthorship W3091849290A5015348925 @default.
• W3091849290 hasAuthorship W3091849290A5019837543 @default.
• W3091849290 hasAuthorship W3091849290A5038672698 @default.
• W3091849290 hasAuthorship W3091849290A5045665341 @default.
• W3091849290 hasAuthorship W3091849290A5064265738 @default.
• W3091849290 hasAuthorship W3091849290A5090411849 @default.
• W3091849290 hasBestOaLocation W30918492901 @default.
• W3091849290 hasConcept C104317684 @default.
• W3091849290 hasConcept C126322002 @default.
• W3091849290 hasConcept C138798377 @default.
• W3091849290 hasConcept C142724271 @default.
• W3091849290 hasConcept C145059251 @default.
• W3091849290 hasConcept C159641895 @default.
• W3091849290 hasConcept C170493617 @default.
• W3091849290 hasConcept C185592680 @default.
• W3091849290 hasConcept C198826908 @default.
• W3091849290 hasConcept C201750760 @default.
• W3091849290 hasConcept C203014093 @default.
• W3091849290 hasConcept C20518536 @default.
• W3091849290 hasConcept C2776634560 @default.
• W3091849290 hasConcept C2780091579 @default.
• W3091849290 hasConcept C2781016617 @default.
• W3091849290 hasConcept C2781243531 @default.
• W3091849290 hasConcept C28328180 @default.
• W3091849290 hasConcept C553184892 @default.
• W3091849290 hasConcept C55493867 @default.
• W3091849290 hasConcept C71924100 @default.
• W3091849290 hasConcept C7876069 @default.
• W3091849290 hasConcept C86803240 @default.
• W3091849290 hasConcept C95444343 @default.
• W3091849290 hasConceptScore W3091849290C104317684 @default.
• W3091849290 hasConceptScore W3091849290C126322002 @default.

• next