Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091850346> ?p ?o ?g. }
- W3091850346 abstract "Abstract Midbrain dopaminergic (mDA) neurons are diverse in their projection targets, impact on behavior and susceptibility to neurodegeneration. Little is known about the molecular mechanisms that establish this diversity in mDA neurons during development. We find that the transcription factor Bcl11a defines a subset of mDA neurons in the developing and adult murine brain. By combining intersectional labeling and viral-mediated tracing we show that Bcl11a-expressing mDA neurons form a highly specific subcircuit within the dopaminergic system. We demonstrate that Bcl11a-expressing mDA neurons in the substantia nigra (SN) are particularly vulnerable to neurodegeneration in an α-synuclein overexpression model of Parkinson’s disease. Inactivation of Bcl11a in developing mDA neurons results in anatomical changes, deficits in motor learning and a dramatic increase in the susceptibility to α-synuclein-induced degeneration in SN-mDA neurons. In summary, we identify an mDA subpopulation with highly distinctive characteristics defined by the expression of the transcription factor Bcl11a already during development." @default.
- W3091850346 created "2020-10-15" @default.
- W3091850346 creator A5000415452 @default.
- W3091850346 creator A5000783282 @default.
- W3091850346 creator A5003212149 @default.
- W3091850346 creator A5006320444 @default.
- W3091850346 creator A5012893828 @default.
- W3091850346 creator A5028804064 @default.
- W3091850346 creator A5032874660 @default.
- W3091850346 creator A5037363783 @default.
- W3091850346 creator A5049770229 @default.
- W3091850346 creator A5050850243 @default.
- W3091850346 creator A5052971257 @default.
- W3091850346 creator A5074022782 @default.
- W3091850346 creator A5077361921 @default.
- W3091850346 creator A5081621611 @default.
- W3091850346 creator A5089045595 @default.
- W3091850346 date "2020-10-07" @default.
- W3091850346 modified "2023-10-01" @default.
- W3091850346 title "The transcription factor BCL11A defines a distinctive subset of dopamine neurons in the developing and adult midbrain" @default.
- W3091850346 cites W1750971820 @default.
- W3091850346 cites W1875506666 @default.
- W3091850346 cites W1909964525 @default.
- W3091850346 cites W1973897139 @default.
- W3091850346 cites W1975032719 @default.
- W3091850346 cites W1978793506 @default.
- W3091850346 cites W2004002023 @default.
- W3091850346 cites W2010395737 @default.
- W3091850346 cites W2027713233 @default.
- W3091850346 cites W2049356130 @default.
- W3091850346 cites W2070635751 @default.
- W3091850346 cites W2076706946 @default.
- W3091850346 cites W2088476185 @default.
- W3091850346 cites W2089522371 @default.
- W3091850346 cites W2095767025 @default.
- W3091850346 cites W2097241494 @default.
- W3091850346 cites W2098027759 @default.
- W3091850346 cites W2107522917 @default.
- W3091850346 cites W2117782909 @default.
- W3091850346 cites W2119079421 @default.
- W3091850346 cites W2129167248 @default.
- W3091850346 cites W2132909766 @default.
- W3091850346 cites W2137608891 @default.
- W3091850346 cites W2142820387 @default.
- W3091850346 cites W2172706654 @default.
- W3091850346 cites W2309693715 @default.
- W3091850346 cites W2336893408 @default.
- W3091850346 cites W2337030209 @default.
- W3091850346 cites W2480659285 @default.
- W3091850346 cites W2528543174 @default.
- W3091850346 cites W2569240731 @default.
- W3091850346 cites W2582439242 @default.
- W3091850346 cites W2785516458 @default.
- W3091850346 cites W2803110575 @default.
- W3091850346 cites W2886986075 @default.
- W3091850346 cites W2887114149 @default.
- W3091850346 cites W2888695486 @default.
- W3091850346 cites W2944116409 @default.
- W3091850346 cites W2945948316 @default.
- W3091850346 cites W2947312223 @default.
- W3091850346 cites W2976998592 @default.
- W3091850346 cites W2996481730 @default.
- W3091850346 cites W3006180028 @default.
- W3091850346 cites W3016182426 @default.
- W3091850346 cites W3036817155 @default.
- W3091850346 doi "https://doi.org/10.1101/2020.10.06.327940" @default.
- W3091850346 hasPublicationYear "2020" @default.
- W3091850346 type Work @default.
- W3091850346 sameAs 3091850346 @default.
- W3091850346 citedByCount "0" @default.
- W3091850346 crossrefType "posted-content" @default.
- W3091850346 hasAuthorship W3091850346A5000415452 @default.
- W3091850346 hasAuthorship W3091850346A5000783282 @default.
- W3091850346 hasAuthorship W3091850346A5003212149 @default.
- W3091850346 hasAuthorship W3091850346A5006320444 @default.
- W3091850346 hasAuthorship W3091850346A5012893828 @default.
- W3091850346 hasAuthorship W3091850346A5028804064 @default.
- W3091850346 hasAuthorship W3091850346A5032874660 @default.
- W3091850346 hasAuthorship W3091850346A5037363783 @default.
- W3091850346 hasAuthorship W3091850346A5049770229 @default.
- W3091850346 hasAuthorship W3091850346A5050850243 @default.
- W3091850346 hasAuthorship W3091850346A5052971257 @default.
- W3091850346 hasAuthorship W3091850346A5074022782 @default.
- W3091850346 hasAuthorship W3091850346A5077361921 @default.
- W3091850346 hasAuthorship W3091850346A5081621611 @default.
- W3091850346 hasAuthorship W3091850346A5089045595 @default.
- W3091850346 hasBestOaLocation W30918503461 @default.
- W3091850346 hasConcept C104317684 @default.
- W3091850346 hasConcept C137183658 @default.
- W3091850346 hasConcept C142724271 @default.
- W3091850346 hasConcept C169760540 @default.
- W3091850346 hasConcept C2776925932 @default.
- W3091850346 hasConcept C2779134260 @default.
- W3091850346 hasConcept C2779734285 @default.
- W3091850346 hasConcept C2780938664 @default.
- W3091850346 hasConcept C513476851 @default.
- W3091850346 hasConcept C529278444 @default.
- W3091850346 hasConcept C54355233 @default.
- W3091850346 hasConcept C552161191 @default.
- W3091850346 hasConcept C71924100 @default.