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- W3091859282 abstract "Abstract Association between vitamin D and uric acid is complex and might be bidirectional. Our study aimed to determine the bidirectional association between vitamin D and uric acid in adults. Using MEDLINE via PubMed and Scopus, we systematically searched for observational or interventional studies in adults, which assessed the association between serum vitamin D and serum uric acid, extracted the data, and conducted analysis by direct and network meta-analysis. The present review included 32 studies, of which 21 had vitamin D as outcome and 11 had uric acid as outcome. Meta-analysis showed a significant pooled beta coefficient of serum uric acid level on serum 25(OH)D level from 3 studies of 0.512 (95% confidence interval: 0.199, 0.825) and a significant pooled odds ratio between vitamin D deficiency and hyperuricemia of 1.496 (1.141, 1.963). The pooled mean difference of serum 25(OH)D between groups with hyperuricemia and normouricemia was non-significant at 0.138 (−0.430, 0.707) ng/ml, and the pooled mean difference of serum uric acid between categories of 25(OH)D were also non-significant at 0.072 (−0.153, 0.298) mg/dl between deficiency and normal, 0.038 (−0.216, 0.292) mg/dl between insufficiency and normal, and 0.034 (−0.216, 0.283) mg/dl between deficiency and insufficiency. In conclusion, increasing serum uric acid might be associated with increasing 25(OH)D level, while vitamin D deficiency is associated with hyperuricemia. These reverse relationships should be further evaluated in a longitudinal study." @default.
- W3091859282 created "2020-10-15" @default.
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- W3091859282 date "2020-10-01" @default.
- W3091859282 modified "2023-10-16" @default.
- W3091859282 title "Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis" @default.
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- W3091859282 doi "https://doi.org/10.1055/a-1240-5850" @default.
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