Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091863501> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3091863501 endingPage "4629" @default.
- W3091863501 startingPage "4629" @default.
- W3091863501 abstract "Background: Structure-activity relationships describe the relationship between chemical structure and biologic activity and are capable of informing deliberate structural modifications to a molecule in order enhance drug properties. Methods: Here, we present a subtle, yet unique twist on structure-activity relationships in which a collective biologic activity was measured among five cinnamon constituents with a shared phenylpropanoid template (cinnamic acid, cinnamaldehyde, chlorogenic acid, caffeic acid, and ferulic acid). This template-based approach utilized publicly available transcriptomic data through the Gene Expression Omnibus (GEO) to identify a fundamental biologic effect; in essence, a phenylpropanoid template effect. Results: The recurrent identification of cytokine-cytokine receptor interaction and neuroactive ligand receptor pathways in each individual treatment condition strongly supports the fact that changes in gene expression within these pathways is a hallmark of the phenylpropanoid template. With a template effect identified, future structural modifications can be performed in order to overcome pharmacokinetic barriers to clinical use (i.e., traditional structure-activity relationship experiments). Moreover, these modifications can be implemented with a high degree of confidence knowing that a consistent and robust template effect is likely to persist. Conclusion: We believe this template-based approach offers researchers an attractive and cost-effective means for evaluating multicomponent natural products during drug development." @default.
- W3091863501 created "2020-10-15" @default.
- W3091863501 creator A5001078818 @default.
- W3091863501 creator A5026180774 @default.
- W3091863501 date "2020-10-11" @default.
- W3091863501 modified "2023-09-25" @default.
- W3091863501 title "A Template-Based Approach for Guiding and Refining the Development of Cinnamon-Based Phenylpropanoids as Drugs" @default.
- W3091863501 cites W1873396860 @default.
- W3091863501 cites W1964647898 @default.
- W3091863501 cites W1965037168 @default.
- W3091863501 cites W1965593909 @default.
- W3091863501 cites W1967601023 @default.
- W3091863501 cites W1993190574 @default.
- W3091863501 cites W1996729117 @default.
- W3091863501 cites W2050170010 @default.
- W3091863501 cites W2070110861 @default.
- W3091863501 cites W2081849608 @default.
- W3091863501 cites W2085669739 @default.
- W3091863501 cites W2090214784 @default.
- W3091863501 cites W2105234557 @default.
- W3091863501 cites W2118742454 @default.
- W3091863501 cites W2127489327 @default.
- W3091863501 cites W2133465414 @default.
- W3091863501 cites W2158217645 @default.
- W3091863501 cites W2341128841 @default.
- W3091863501 cites W2342805349 @default.
- W3091863501 cites W2595454228 @default.
- W3091863501 cites W2613772269 @default.
- W3091863501 cites W2737118427 @default.
- W3091863501 cites W2938493336 @default.
- W3091863501 cites W2946872927 @default.
- W3091863501 doi "https://doi.org/10.3390/molecules25204629" @default.
- W3091863501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7587175" @default.
- W3091863501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33050677" @default.
- W3091863501 hasPublicationYear "2020" @default.
- W3091863501 type Work @default.
- W3091863501 sameAs 3091863501 @default.
- W3091863501 citedByCount "0" @default.
- W3091863501 crossrefType "journal-article" @default.
- W3091863501 hasAuthorship W3091863501A5001078818 @default.
- W3091863501 hasAuthorship W3091863501A5026180774 @default.
- W3091863501 hasBestOaLocation W30918635011 @default.
- W3091863501 hasConcept C104317684 @default.
- W3091863501 hasConcept C185592680 @default.
- W3091863501 hasConcept C2776559899 @default.
- W3091863501 hasConcept C2778831176 @default.
- W3091863501 hasConcept C2779396153 @default.
- W3091863501 hasConcept C553450214 @default.
- W3091863501 hasConcept C55493867 @default.
- W3091863501 hasConcept C70721500 @default.
- W3091863501 hasConcept C74187038 @default.
- W3091863501 hasConcept C86803240 @default.
- W3091863501 hasConceptScore W3091863501C104317684 @default.
- W3091863501 hasConceptScore W3091863501C185592680 @default.
- W3091863501 hasConceptScore W3091863501C2776559899 @default.
- W3091863501 hasConceptScore W3091863501C2778831176 @default.
- W3091863501 hasConceptScore W3091863501C2779396153 @default.
- W3091863501 hasConceptScore W3091863501C553450214 @default.
- W3091863501 hasConceptScore W3091863501C55493867 @default.
- W3091863501 hasConceptScore W3091863501C70721500 @default.
- W3091863501 hasConceptScore W3091863501C74187038 @default.
- W3091863501 hasConceptScore W3091863501C86803240 @default.
- W3091863501 hasIssue "20" @default.
- W3091863501 hasLocation W30918635011 @default.
- W3091863501 hasLocation W30918635012 @default.
- W3091863501 hasOpenAccess W3091863501 @default.
- W3091863501 hasPrimaryLocation W30918635011 @default.
- W3091863501 hasRelatedWork W169331422 @default.
- W3091863501 hasRelatedWork W1981508461 @default.
- W3091863501 hasRelatedWork W2002742328 @default.
- W3091863501 hasRelatedWork W2088226047 @default.
- W3091863501 hasRelatedWork W2283333729 @default.
- W3091863501 hasRelatedWork W2325550854 @default.
- W3091863501 hasRelatedWork W2580346700 @default.
- W3091863501 hasRelatedWork W2913559315 @default.
- W3091863501 hasRelatedWork W3161822132 @default.
- W3091863501 hasRelatedWork W91016845 @default.
- W3091863501 hasVolume "25" @default.
- W3091863501 isParatext "false" @default.
- W3091863501 isRetracted "false" @default.
- W3091863501 magId "3091863501" @default.
- W3091863501 workType "article" @default.