Matches in SemOpenAlex for { <https://semopenalex.org/work/W3091887727> ?p ?o ?g. }
- W3091887727 abstract "ABSTRACT PTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the transcriptional changes associated with PTEN loss in PCa have not been described in detail. Here, we applied a meta-analysis approach, leveraging two large PCa cohorts with experimentally validated PTEN and ERG status, to derive a transcriptomic signature of PTEN loss, while also accounting for potential confounders due to ERG rearrangements. Strikingly, the signature indicates a strong activation of both innate and adaptive immune systems upon PTEN loss, as well as an expected activation of cell-cycle genes. Moreover, we made use of our recently developed FC-R2 expression atlas to expand this signature to include many non-coding RNAs recently annotated by the FANTOM consortium. With this resource, we analyzed the TCGA-PRAD cohort, creating a comprehensive transcriptomic landscape of PTEN loss in PCa that comprises both the coding and an extensive non-coding counterpart." @default.
- W3091887727 created "2020-10-15" @default.
- W3091887727 creator A5000560433 @default.
- W3091887727 creator A5008552473 @default.
- W3091887727 creator A5010499534 @default.
- W3091887727 creator A5013881851 @default.
- W3091887727 creator A5027111342 @default.
- W3091887727 creator A5030368661 @default.
- W3091887727 creator A5047383259 @default.
- W3091887727 creator A5049753330 @default.
- W3091887727 creator A5060357821 @default.
- W3091887727 creator A5071763026 @default.
- W3091887727 creator A5079978893 @default.
- W3091887727 creator A5087878944 @default.
- W3091887727 date "2020-10-09" @default.
- W3091887727 modified "2023-10-14" @default.
- W3091887727 title "Transcriptional landscape of PTEN loss in primary prostate cancer" @default.
- W3091887727 cites W1499694647 @default.
- W3091887727 cites W1508662657 @default.
- W3091887727 cites W1964116972 @default.
- W3091887727 cites W1966230453 @default.
- W3091887727 cites W1970501568 @default.
- W3091887727 cites W1972270538 @default.
- W3091887727 cites W1974270882 @default.
- W3091887727 cites W1974558929 @default.
- W3091887727 cites W1974720903 @default.
- W3091887727 cites W1976730154 @default.
- W3091887727 cites W1978089688 @default.
- W3091887727 cites W1994269934 @default.
- W3091887727 cites W1996913705 @default.
- W3091887727 cites W2001571771 @default.
- W3091887727 cites W2004181696 @default.
- W3091887727 cites W2004477123 @default.
- W3091887727 cites W2005296614 @default.
- W3091887727 cites W2010457001 @default.
- W3091887727 cites W2015598035 @default.
- W3091887727 cites W2025487619 @default.
- W3091887727 cites W2039543196 @default.
- W3091887727 cites W2045119066 @default.
- W3091887727 cites W2049205984 @default.
- W3091887727 cites W2066840282 @default.
- W3091887727 cites W2072620890 @default.
- W3091887727 cites W2073100248 @default.
- W3091887727 cites W2075648742 @default.
- W3091887727 cites W2081098333 @default.
- W3091887727 cites W2087207490 @default.
- W3091887727 cites W2091491108 @default.
- W3091887727 cites W2092708210 @default.
- W3091887727 cites W2092979611 @default.
- W3091887727 cites W2095059750 @default.
- W3091887727 cites W2096277507 @default.
- W3091887727 cites W2098250732 @default.
- W3091887727 cites W2107633226 @default.
- W3091887727 cites W2116371946 @default.
- W3091887727 cites W2124194872 @default.
- W3091887727 cites W2126008912 @default.
- W3091887727 cites W2128613144 @default.
- W3091887727 cites W2129269286 @default.
- W3091887727 cites W2130200307 @default.
- W3091887727 cites W2130410032 @default.
- W3091887727 cites W2137526110 @default.
- W3091887727 cites W2158485828 @default.
- W3091887727 cites W2160714232 @default.
- W3091887727 cites W2161112598 @default.
- W3091887727 cites W2168565140 @default.
- W3091887727 cites W2173477069 @default.
- W3091887727 cites W2196159484 @default.
- W3091887727 cites W2207649948 @default.
- W3091887727 cites W2264492011 @default.
- W3091887727 cites W2296343843 @default.
- W3091887727 cites W2344610509 @default.
- W3091887727 cites W2492448981 @default.
- W3091887727 cites W2530822278 @default.
- W3091887727 cites W2547629658 @default.
- W3091887727 cites W2570076470 @default.
- W3091887727 cites W2593488635 @default.
- W3091887727 cites W2736216151 @default.
- W3091887727 cites W2742218158 @default.
- W3091887727 cites W2782563507 @default.
- W3091887727 cites W2788783025 @default.
- W3091887727 cites W2806930349 @default.
- W3091887727 cites W2807832759 @default.
- W3091887727 cites W2889318399 @default.
- W3091887727 cites W2895347925 @default.
- W3091887727 cites W2898919442 @default.
- W3091887727 cites W2909513097 @default.
- W3091887727 cites W3007465583 @default.
- W3091887727 cites W3015265197 @default.
- W3091887727 cites W3019565062 @default.
- W3091887727 cites W4211195653 @default.
- W3091887727 doi "https://doi.org/10.1101/2020.10.08.332049" @default.
- W3091887727 hasPublicationYear "2020" @default.
- W3091887727 type Work @default.
- W3091887727 sameAs 3091887727 @default.
- W3091887727 citedByCount "2" @default.
- W3091887727 countsByYear W30918877272022 @default.
- W3091887727 countsByYear W30918877272023 @default.
- W3091887727 crossrefType "posted-content" @default.
- W3091887727 hasAuthorship W3091887727A5000560433 @default.
- W3091887727 hasAuthorship W3091887727A5008552473 @default.