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- W3091894764 abstract "Background: Abuse of analgesic and sedative drugs often leads to severe respiratory depression and sometimes death. Approximately 69,000 people worldwide die annually from opioid overdoses. Purpose: This work aimed to investigate whether CX1739 can be used for emergency treatment of acute respiratory depression due to drug abuse. Results: First, the results clarify that CX1739 is a low-impact ampakine that can safely activate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors without causing excito-neurotoxicity. Second, CX1739 rapidly crossed the blood–brain barrier (T max = 2 min), which meets the requirement of rapid onset of action in vivo. Our work provides preliminarily confirmation that high-dose intravenous administration of CX1739 can immediately reverse respiratory depression in animal models of respiratory depression caused by opioid agonist 030418, pentobarbital sodium and ethanol." @default.
- W3091894764 created "2020-10-15" @default.
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- W3091894764 date "2020-12-01" @default.
- W3091894764 modified "2023-10-13" @default.
- W3091894764 title "The impact and mechanism of ampakine CX1739 on protection against respiratory depression in rats" @default.
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- W3091894764 doi "https://doi.org/10.4155/fmc-2020-0256" @default.
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