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- W3091897065 abstract "Regulation of genome-wide DNA methylation is fundamental for a variety of biological processes such as mammalian development, stem cell function, cellular proliferation/differentiation, and oncogenesis. Among the regulators of DNA methylation, ten-eleven translocation 2 (TET2) is one of the most frequently mutated genes in clonal hematopoiesis of indeterminate potential and in various hematological malignancies, underscoring a pivotal role for TET2 in blood homeostasis and hematopoietic transformation. TET2 oxidizes methylated cytosines to further modify cytosines, which behave as intermediates in active/passive DNA demethylation processes. TET2 itself associates with histone modifiers, thereby regulating histone modifications and expression of target genes. A number of studies have reported pleiotropic effects of TET2 on hematopoietic stem cell self-renewal, hematopoietic differentiation, genome instability and inflammatory response. Recent single-cell genomics studies have identified gene promoters as well as transcription factor binding sites as TET2-targeted genetic loci in which disruption of DNA methylation can fundamentally modify hematopoietic differentiation and promote leukemogenesis. TET2 mutations show convergent cooperativity with other disease alleles in signaling molecules, epigenetic modifiers, and spliceosome factors in hematopoietic transformation. Future studies focusing on the molecular basis of stem cell and immune regulation by TET2 loss will further deepen our understanding of the entire landscape of pathophysiology and molecular vulnerabilities of TET2-mutated hematological malignancies." @default.
- W3091897065 created "2020-10-15" @default.
- W3091897065 creator A5036193214 @default.
- W3091897065 creator A5052090382 @default.
- W3091897065 date "2020-11-18" @default.
- W3091897065 modified "2023-10-13" @default.
- W3091897065 title "TET2: A cornerstone in normal and malignant hematopoiesis" @default.
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- W3091897065 doi "https://doi.org/10.1111/cas.14688" @default.
- W3091897065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7780023" @default.
- W3091897065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33048426" @default.
- W3091897065 hasPublicationYear "2020" @default.
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