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- W3091904051 abstract "Background: Pancreatic neuroendocrine tumors (panNET) are rare neoplasms that account for approximately 7% of all neuroendocrine tumors and 1% to 2% of pancreatic tumors. Material and Methods: An observational, descriptive, retrospective study was performed in patients with diagnosis of NET treated at Hospital Clínico Universitario de Valladolid (Spain) between 2000 and 2018. Results: In the study period, 149 cases of NET were diagnosed; 26 (17%) were panNET. 19 cases (73,1%) were females and the median age was 68,2 (range 40-90). 1 case (3,8%) of carcinoid syndrome. Asymptomatic patients were 6 (23,1%). Main symptoms were: delirium in 2 cases (7,7%); hypoglycemia 5 (19,2%); lethargy 6 (23,1%); diarrhea 3 (11,5%); weight loss: 4 (15,4%) abdominal pain: 7 (26,9%); jaundice: 1 (3,8%); GI bleeding 1 (3,8%). Tumor median size was 28,08mm (8-73mm). WHO grade, (2010) was for G1: 17 (65,4%), G2: 3 (11,5%) and G3: 6 (23,1%). All the incidental diagnosis happened after 2013. Staging: (TNM 8th ed., 2017) I: 13 (50%); II: 1 (3,8%); III: 3 (11,5%); IV: 9 (34,6%). 7 patients (26,9%) had other synchronic neoplasias: 1 thyroid cancer (3,8%), 2 breast cancer (7,7%), 1 gastric cancer (3,8%) and 3 renal cancer (11,5%). In 1 patient, hyperparathyroidism and MEN-1 syndrome were diagnosed in the follow up period. 18 patients (69,3%) were operated on. The Results are shown in the table. Pathological reports shown (surgical specimen or biopsy): 11 (42%) non-functioning panNET, 5 (19,2%) insulinoma, 4 (15,4%) NETcarcinoma, 3 (11,5%) gastrinoma, 1 (3,8%) glucagonoma, 1 ACTHoma and 1 NETcarcinoid. Period of follow up was from 3 to 107 months. 8 patients (30,7%) died during follow up. Conclusion: PanNET are a heterogeneous group of neoplasms with different clinical manifestations, behavior and prognosis and their multidisciplinary approach is mandatory. The availability of high-quality imaging techniques has made the incidental diagnosis more frequent nowadays. Tabled 1Caption 1: Table." @default.
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- W3091904051 date "2020-01-01" @default.
- W3091904051 modified "2023-09-29" @default.
- W3091904051 title "Pancreatic neuroendocrine tumors: experience at a tertiary university hospital. (2000 - 2018)" @default.
- W3091904051 doi "https://doi.org/10.1016/j.hpb.2020.04.244" @default.
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